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Titolo:
Low carotenoid concentration and the risk of HIV seroconversion in Pune, India
Autore:
Mehendale, SM; Shepherd, ME; Brookmeyer, RS; Semba, RD; Divekar, AD; Gangakhedkar, RR; Joshi, S; Risbud, AR; Paranjape, RS; Gadkari, DA; Bollinger, RC;
Indirizzi:
Natl AIDS Res Inst, Pune 411026, Maharashtra, India Natl AIDS Res Inst Pune Maharashtra India 411026 1026, Maharashtra, India Natl Inst Virol, Pune, Maharashtra, India Natl Inst Virol Pune Maharashtra India t Virol, Pune, Maharashtra, India Johns Hopkins Univ, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ohns Hopkins Univ, Baltimore, MD USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 26, anno: 2001,
pagine: 352 - 359
SICI:
1525-4135(20010401)26:4<352:LCCATR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-A-DEFICIENCY; ALPHA-TOCOPHEROL; IMMUNE-RESPONSE; BETA-CAROTENE; INFECTION; CHILDREN; SERUM; ASSOCIATION; MORTALITY; RETINOL;
Keywords:
carotenoids; seroconversion; vitamin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Mehendale, SM Natl AIDS Res Inst, Plot 73 G Block MIDC, Pune 411026, Maharashtra, India Natl AIDS Res Inst Plot 73 G Block MIDC Pune Maharashtra India 411026
Citazione:
S.M. Mehendale et al., "Low carotenoid concentration and the risk of HIV seroconversion in Pune, India", J ACQ IMM D, 26(4), 2001, pp. 352-359

Abstract

Low vitamin A and carotenoid levels could increase the risk of sexual HIV acquisition by altering the integrity of the genital epithelium or by immunologic dysfunction. We addressed this issue by measuring serum vitamin A and carotenoid levels in patients who were at risk of subsequent HIV infection. In a nested case-control study in individuals attending two sexually transmitted disease (STD) clinics in Pune, India, serum micronutrient levels were measured in 44 cases with documented HIV seroconversion (11 women and 33 men) and in STD patients matched for gender and length of follow-up with no subsequent HIV seroconversion (controls). STD patients in Pune had low vitamin A and carotenoid levels, and low serum beta -carotene levels were independently associated with an increased risk of subsequent HIV seroconversion. STD patients with beta -carotene levels less than 0.075 mu mol/L were 21 times more likely to acquire KTV infection than those with higher levels(adjusted odds ratio = 21.1; p = .01). No such association was observed incase of other non-provitamin A carotenoids. This study reports the first evidence of an association between low serum provitamin A carotenoid levels and an increased risk for heterosexual HIV acquisition in STD patients in Pune, India.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 01:30:18