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Titolo:
HIV seroconversion during pregnancy and risk for mother-to-infant transmission
Autore:
Roongpisuthipong, A; Siriwasin, W; Simonds, RJ; Sangtaweesin, V; Vanprapar, N; Wasi, C; Singhanati, S; Mock, P; Young, N; Parekh, B; Mastro, TD; Shaffer, N;
Indirizzi:
HIV AIDS Collaborat, Minist Publ Hlth, Nonthaburi 11000, Thailand HIV AIDSCollaborat Nonthaburi Thailand 11000 Nonthaburi 11000, Thailand Mahidol Univ, Fac Med, Siriraj Hosp, Dept Obstet & Gynecol, Bangkok 10700,Thailand Mahidol Univ Bangkok Thailand 10700 et & Gynecol, Bangkok 10700,Thailand Mahidol Univ, Fac Med, Siriraj Hosp, Dept Pediat, Bangkok 10700, Thailand Mahidol Univ Bangkok Thailand 10700 Dept Pediat, Bangkok 10700, Thailand Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand Mahidol Univ Bangkok Thailand 10700 t Microbiol, Bangkok 10700, Thailand Rajavithi Hosp, Dept Obstet & Gynecol, Dept Med Serv, Minist Publ Hlth, Bangkok, Thailand Rajavithi Hosp Bangkok Thailand rv, Minist Publ Hlth, Bangkok, Thailand Queen Sirikit Natl Inst Child Hlth, Dept Med Serv, Minist Publ Hlth, Bangkok, Thailand Queen Sirikit Natl Inst Child Hlth Bangkok Thailand , Bangkok, Thailand Rajavithi Hosp, Dept Med Serv, Minist Publ Hlth, Bangkok, Thailand Rajavithi Hosp Bangkok Thailand rv, Minist Publ Hlth, Bangkok, Thailand Natl Ctr HIV STD & TB Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Atlanta, GA USA Natl Ctr HIV STD & TB Prevent Atlanta GA USA Epidemiol, Atlanta, GA USA Ctr Dis Control & Prevent, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis,Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA Ctr Infect Dis,Atlanta, GA USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 26, anno: 2001,
pagine: 348 - 351
SICI:
1525-4135(20010401)26:4<348:HSDPAR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTION; THAILAND; BANGKOK; LOAD;
Keywords:
HIV; perinatal transmission; pregnancy; seroconversion; Thailand; viral load;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Simonds, RJ HIV AIDS Collaborat, Minist Publ Hlth, DMS 6 Bldg,Tivanon Rd, Nonthaburi 11000, Thailand HIV AIDS Collaborat DMS 6 Bldg,Tivanon Rd Nonthaburi Thailand 11000
Citazione:
A. Roongpisuthipong et al., "HIV seroconversion during pregnancy and risk for mother-to-infant transmission", J ACQ IMM D, 26(4), 2001, pp. 348-351

Abstract

Pregnant women infected with HIV-1 were enrolled in a prospective mother-to-infant transmission study from 1992 through 1994 in Bangkok. In participating hospitals, voluntary HIV testing was routinely offered at the beginning of antenatal care and again in the middle of the third trimester of pregnancy. Women who seroconverted to HIV during pregnancy were compared with women who had tested positive on their first antenatal test. Maternal HIV RNAlevels were determined during pregnancy, at delivery, and postpartum usingRNA polymerase chain reaction (PCR), and infection status in infants was determined by DNA PCR. Na infants were breastfed, but prophylactic antiretroviral therapy was not yet used in Thailand to prevent transmission from mother to infant. Among enrolled women, 16 who seroconverted during pregnancy and 279 who were HIV-l-seropositive at their first antenatal test gave birth, Median plasma RNA levels at delivery were similar for the two groups (17,505 and 20,845 copies/ml, respectively; p = .8). Two (13.3%) of 15 infantsborn to women who seroconverted and 66 (24.8%) of 266 infants born to previously HIV-seropositive women were infected with HIV (p = .5). There was noincreased risk for mother-to-infant HSV transmission and no significant difference in viral load at delivery between HIV-infected women who seroconverted to HIV during pregnancy and those who were HIV-seropositive when firsttested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:57:04