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Titolo:
Effect of coexisting HIV-1 infection on the diagnosis and evaluation of hepatitis C virus
Autore:
Bonacini, M; Lin, HJ; Hollinger, FB;
Indirizzi:
Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Sch Med, Los Angeles, CA 90033 USA Rancho Los Amigos Natl Rehabil Ctr, Liver Unit, Downey, CA USA Rancho Los Amigos Natl Rehabil Ctr Downey CA USA er Unit, Downey, CA USA Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 26, anno: 2001,
pagine: 340 - 344
SICI:
1525-4135(20010401)26:4<340:EOCHIO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; LIVER-DISEASE; NATURAL-HISTORY; RNA LEVELS; HCV RNA; HEMOPHILIACS; VIREMIA; REPLICATION; PROGRESSION; ANTIBODY;
Keywords:
HIV infections; HCV viral load risk factors; hepatitis C virus; hepatitis B virus; seroprevalence; viral infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Bonacini, M Univ So Calif, Keck Sch Med, HMR 101,2011 Zonal Ave, Los Angeles, CA 90033USA Univ So Calif HMR 101,2011 Zonal Ave Los Angeles CA USA 90033
Citazione:
M. Bonacini et al., "Effect of coexisting HIV-1 infection on the diagnosis and evaluation of hepatitis C virus", J ACQ IMM D, 26(4), 2001, pp. 340-344

Abstract

Objectives: To evaluate the diagnostic accuracy of the test for antibodiesto hepatitis C virus by enzyme-linked immunosorbent assay (anti-HCV ELISA-2) in patients with and without HIV-1 infection. Design: Cohort study. Methods: In all, 369 patients were tested and grouped by available serologic tests. I-ICV RNA was quantified in these 369 patients using an Amplicor HCV (and/or HIV-1) Monitor, v1.0 test. Among 110 patients who were anti-HCVnegative by ELISA-2, 39 were HIV/HBV coinfected and 71 had HIV alone. One hundred twelve patients were HIV/HCV coinfected and 147 patients had HCV infection alone. Results: Six of 110 (5.5%) ELISA-2 anti-HCV-negative, HIV-infected patients had circulating serum HCV RNA. Their median CD4 count was 36 cells/mm(3),which was significantly lower than that observed in the HIV/HBV group (median CD4 = 109, p < .001) or the HIV/HCV cohort (CD4 = 235; p < .0001). The positive predictive value of the ELISA-2 test for diagnosing ongoing HCV infection in HIV-infected patients was 91%, which is significantly better than that determined for the HCV group, 76% (p = .002) presumably because HCV is less likely to resolve in the HIV patients. Mean alanine aminotransferase (ALT) levels were similar in the HIV/HCV (133 IU/L) and HCV (130 IU/L) cohorts. Median HCV RNA levels were higher in the HIV/HCV group (6.53 log(10)copies/ml) compared with the patients with HCV infection (5.62 log(10) copies/ml; p < .00001). There was no significant correlation between HCV RNA levels and ALT values, CD4 counts, or HIV RNA concentrations. Conclusions: The predictive value of the anti-HCV ELISA-2 test is better in HIV-coinfected patients than in patients infected only with HCV. False negative results, usually associated with acute infection or with Low CD4 counts, are uncommon. These patients may be diagnosed with the ELISA-3 assay or by reverse transcriptase polymerase chain reaction (RT-PCR). Compared with patients with only HCV infection, HIV/HCV patients display similar ALT profiles, but a higher proportion of detectable serum HCV RNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:15:43