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Titolo:
Qualitative and quantitative PCR measures of cytomegalovirus in patients with advanced HIV infection who require transfusions
Autore:
Para, MF; Kalish, LA; Collier, AC; Pollard, RB; Kumar, PN; Mintz, L; Wallach, FR; Drew, WL;
Indirizzi:
Ohio State Univ, Med Ctr, Dept Med, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 r, Dept Med, Columbus, OH 43210 USA New England Res Inst, Watertown, MA 02172 USA New England Res Inst Watertown MA USA 02172 Inst, Watertown, MA 02172 USA Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA Univ WashingtonSeattle WA USA 98195 Med, Dept Med, Seattle, WA 98195 USA Univ Texas, Dept Med, Galveston, TX 77555 USA Univ Texas Galveston TX USA77555 exas, Dept Med, Galveston, TX 77555 USA Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ept Med, Washington, DC 20007 USA Mt Sinai Sch Med, Dept Med, New York, NY USA Mt Sinai Sch Med New York NYUSA nai Sch Med, Dept Med, New York, NY USA Univ Calif San Francisco, Mt Zion Med Ctr, San Francisco, CA 94120 USA Univ Calif San Francisco San Francisco CA USA 94120 ancisco, CA 94120 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 26, anno: 2001,
pagine: 320 - 325
SICI:
1525-4135(20010401)26:4<320:QAQPMO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; ACTIVE ANTIRETROVIRAL THERAPY; AIDS PATIENTS; POSITIVE PATIENTS; PROTEASE INHIBITORS; CMV DISEASE; RETINITIS; PLASMA; RISK; GANCICLOVIR;
Keywords:
transfusion; cytomegalovirus; CMV-PCR; Karnofsky;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Para, MF Ohio State Univ, Med Ctr, Dept Med, 456 W 10th Ave,Room 4725, Columbus, OH43210 USA Ohio State Univ 456 W 10th Ave,Room 4725 Columbus OH USA43210 SA
Citazione:
M.F. Para et al., "Qualitative and quantitative PCR measures of cytomegalovirus in patients with advanced HIV infection who require transfusions", J ACQ IMM D, 26(4), 2001, pp. 320-325

Abstract

The Viral Activation Transfusion Study (VATS) was a randomized trial that compared leukocyte-reduced transfusions with unfiltered red blood cell transfusions in HIV and cytomegalovirus (CMV) antibody-positive patients with anemia who were undergoing their first blood transfusion. The relations of the baseline qualitative and quantitative polymerase chain reaction (PCR) measures of plasma CMV viremia, HIV RNA, CD4(+) cell counts, and quality of life in these study subjects were examined. The 511 study subjects had a median CD4(+) cell count equal to 15 cells/mm(3), and 110 (21.5%) had CMV viremia by qualitative assay. In multivariate models, frequency of positive qualitative CMV increased with decreasing CD4(+) cell counts (p = .04 trend), higher HIV RNA (p < .001), and a history of CMV disease (p < .001). Quantitative CMV PCR were performed on the 110 qualitative assay-positive study subjects. Median CMV viral load was 1780 copies/ml. In multivariate regression models, lower CD4(+) cell count (p = .03), and a history of CMV disease (p < .001) correlated with the level of CMV load. HIV RNA load and CMV load were not correlated. A lower Karnofsky score was associated with both the presence and quantity of CMV DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:37:45