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Titolo:
In vivo cardiovascular effects of the new atypical neuroleptic sertindole
Autore:
Agelink, MW; Zeit, T; Baumann, B; Majewski, T; Lemmer, W; Postert, T; Lukas, K; Klieser, E;
Indirizzi:
Gelsenkirchen Evangel Clin, Dept Psychiat, Cologne, Germany Gelsenkirchen Evangel Clin Cologne Germany t Psychiat, Cologne, Germany Gelsenkirchen Evangel Clin, Dept Internal Med, Cologne, Germany Gelsenkirchen Evangel Clin Cologne Germany ternal Med, Cologne, Germany Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, Bochum, Germany Ruhr Univ Bochum Bochum Germany osef Hosp, Dept Neurol, Bochum, Germany Otto von Guericke Univ, Dept Psychiat, Magdeburg, Germany Otto von Guericke Univ Magdeburg Germany t Psychiat, Magdeburg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
fascicolo: 1, volume: 5, anno: 2001,
pagine: 33 - 40
SICI:
1365-1501(200103)5:1<33:IVCEOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; ACUTE MYOCARDIAL-INFARCTION; AUTONOMIC NERVOUS-SYSTEM; TORSADES-DE-POINTES; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; QT INTERVAL; VENTRICULAR-FIBRILLATION; SYMPATHOVAGAL BALANCE; ANTIPSYCHOTIC-DRUGS;
Keywords:
schizophrenia; neuroleptic; heart rate variability; electrocardiography; torsades de pointes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Agelink, MW Ruhr Univ Bochum, Psychiat Klin, Evangel Kliniken Gelsenkirchen, Munckelstr 27, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Munckelstr 27 Gelsenkirchen Germany D-45879
Citazione:
M.W. Agelink et al., "In vivo cardiovascular effects of the new atypical neuroleptic sertindole", INT J PSYC, 5(1), 2001, pp. 33-40

Abstract

INTRODUCTION: The goal of this open clinical study was to perform a detailed investigation of the cardiovascular Effects of the novel atypical neuroleptic sertindole. METHOD: Thirty initially untreated schizophrenic inpatients (diagnosed according to DSM-III-R) underwent a total of 103 serial recordings of standardized autonomic rests during a sertindole dose titration programme (4-16 mg/d), The autonomic test battery included: (1) conventional ECGs with 12 channels, (2) computer-assisted analysis of the 5-min resting heart rate variability (HRV); (3) HRV during standard autonomic reflex rests (deep-breathingtest, 30: 15 ratio); and (4) blood pressure measurement under vesting conditions and during orthostatic stress (Schellong test). Reference values forthe HRV study were obtained from healthy controls (n=80). RESULTS: The most important findings were: (1) sertindole significantly increased the vesting heart rate; (2) sertindole induced a significant and probably dose-dependent prolongation of the frequency-corrected QT-times, while mean PQ-conduction times remained unchanged; (3) sertindole had no significant affects on autonomic parasympathetic tone, both in the vesting studyand following the autonomic reflex tests; and (4) sertindole at doses between 4 and 16 mg/d did not significantly influence blood pressure either under vesting conditions or during orthostatic stress. CONCLUSION: The implications of these findings for the cardiovascular safety and tolerance of sertindole are discussed comprehensively, while considering the pathophysiologically relevant mechanisms underlying the appearanceof life-threatening cardiac arrhythmias and sudden cardiac death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:51:49