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Titolo:
Cardiovascular reflexes during treatment of social phobia with moclobemide
Autore:
Coupland, NJ; Bell, C; Potokar, JP; Bailey, JE; Nutt, DJ;
Indirizzi:
Univ Bristol, Psychopharmacol Unit, Bristol, Avon, England Univ Bristol Bristol Avon England pharmacol Unit, Bristol, Avon, England
Titolo Testata:
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
fascicolo: 1, volume: 5, anno: 2001,
pagine: 27 - 31
SICI:
1365-1501(200103)5:1<27:CRDTOS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE INHIBITORS; BLOOD-PRESSURE MEASUREMENT; ANXIETY DISORDERS; PUBLIC SPEAKING; PHENELZINE; FLUOXETINE; RESPONSIVITY; TRIAL;
Keywords:
social phobia; autonomic nervous system; antidepressant; monoamine oxidase inhibitor; blood pressure monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Coupland, NJ Univ Alberta, Dept Psychiat, Room 1E7-13 Mackenzie Ctr,8440-112 St, Edmonton, AB T6G 2B7, Canada Univ Alberta Room 1E7-13 Mackenzie Ctr,8440-112 St Edmonton AB Canada T6G 2B7
Citazione:
N.J. Coupland et al., "Cardiovascular reflexes during treatment of social phobia with moclobemide", INT J PSYC, 5(1), 2001, pp. 27-31

Abstract

INTRODUCTION: Cardiovascular side-effects are less frequent with moclobemide than with tricyclic or monoamine oxidase inhibitor antidepressants. We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taking a stable dose of moclobemide for a median of 7 weeks. METHOD: Cardiovascular reflex responses to standing, deep breathing and the Valsalva manoeuvre were assessed using beat-by-beat blood pressure and heart rate recording,RESULTS: Moclobemide produced a statistically significant, but clinically modest, degree of improvement in social phobia symptoms. Only the maximum change in heart rate from supine to standing showed a change from before to after treatment, which was not statistically significant after Bonferroni correction, and there was no consistent pattern of altered sympathetic or parasympathetic function. CONCLUSION: Moclobemide is relatively devoid of cardiovascular autonomic effects in physically healthy subjects with social phobia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:48:31