Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Proteomics in neuropsychiatric disorders
Autore:
Rohlff, C;
Indirizzi:
Oxford GlycoSci, Abingdon OX14 3YS, Oxon, England Oxford GlycoSci Abingdon Oxon England OX14 3YS on OX14 3YS, Oxon, England
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 93 - 102
SICI:
1461-1457(200103)4:1<93:PIND>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER CAPTURE MICRODISSECTION; MONOZYGOTIC TWINS DISCORDANT; CEREBROSPINAL-FLUID LEVELS; AMYLOID PRECURSOR PROTEIN; MOOD-STABILIZING AGENTS; ALZHEIMERS-DISEASE; BIPOLAR DISORDER; N-CAM; SCHIZOPHRENIC-PATIENTS; DEPRESSED-PATIENTS;
Keywords:
brain; cerebrospinal fluid (CSF); proteomics; psychiatric disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Rohlff, C Oxford GlycoSci, 10 The Quadrant,Abingdon Sci Pk, Abingdon OX14 3YS, Oxon,England Oxford GlycoSci 10 The Quadrant,Abingdon Sci Pk Abingdon Oxon England OX14 3YS
Citazione:
C. Rohlff, "Proteomics in neuropsychiatric disorders", IN J NEUROP, 4(1), 2001, pp. 93-102

Abstract

Assessing human cerebrospinal fluid (CSF) provides a practical way to conduct longitudinal molecular analyses of changes during the course of neurological disease. Integrated and parallel analyses of neurotransmitters, neuropeptides and proteins in CSF may reveal better insights into complex interaction of numerous cell types in the central nervous system (CNS) at an unprecedented level of complexity and detail. Intricate molecular fingerprints of CSF proteins may pinpoint multiple underlying pathogenic mechanisms as well as an acute and a chronic CNS disease component. Some of these changes may be mapped to altered protein expression patterns in clinically relevantcell populations with a causative or diagnostic disease link. A CNS proteome database of primary human CNS tissues may avoid ambiguities of experimental models and accelerate pre- and clinical development of more specific diagnostic and prognostic disease markers and new selective therapeutics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:09:52