Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Emerging technologies for large-scale screening of human tissues and fluids in the study of severe psychiatric disease
Autore:
Johnston-Wilson, NL; Bouton, CMLS; Pevsner, J; Breen, JJ; Torrey, EF; Yolken, RH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Stranley Div Dev Neurovirol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 ovirol, Baltimore, MD 21287 USA Kennedy Krieger Inst, Dept Neurol, Baltimore, MD USA Kennedy Krieger InstBaltimore MD USA st, Dept Neurol, Baltimore, MD USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Ciphergen Biosys Inc, Palo Alto, CA USA Ciphergen Biosys Inc Palo Alto CAUSA rgen Biosys Inc, Palo Alto, CA USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 83 - 92
SICI:
1461-1457(200103)4:1<83:ETFLSO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR DISORDER; BRAIN PROTEINS; SCHIZOPHRENIA;
Keywords:
cDNA libraries; DRAGON; two-dimensional gel electrophoresis; SELDI; electronic differential display;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Yolken, RH Johns Hopkins Univ, Sch Med, Stranley Div Dev Neurovirol, 600 NWolfe St,Blalock 1106, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St,Blalock 1106 Baltimore MD USA 21287
Citazione:
N.L. Johnston-Wilson et al., "Emerging technologies for large-scale screening of human tissues and fluids in the study of severe psychiatric disease", IN J NEUROP, 4(1), 2001, pp. 83-92

Abstract

Neuropsychiatric diseases such as schizophrenia and bipolar disorder are major causes of morbidity throughout the world. Despite extensive searches, no single gene, RNA transcript, or protein has been found which can, on itsown, account for these disorders. Recently, the availability of genomic tools such as cDNA microarrays, serial analysis of gene expression (SAGE) andlarge-scale sequencing of cDNA libraries has allowed researchers to assay biological samples for a large number of RNA transcripts. Similarly, proteomic tools allow for the quantitation of a large number of peptides and proteins. These methods include two-dimensional electrophoresis and surface-enhanced laser desorption/ionization (SELDI). We have initiated experiments which apply these techniques to the comparison of RNAs and proteins expressedin clinical samples obtained from individuals with psychiatric diseases and controls. These methods have the potential to identify pathways that are involved in the pathogenesis of complex psychiatric disorders. The characterization of these pathways may allow for the development of new methods forthe diagnosis and treatment of schizophrenia, bipolar disorder, and other human psychiatric diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:08:53