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Titolo:
Identification of mood stabilizer-regulated genes by differential-display PCR
Autore:
Wang, JF; Bown, CD; Chen, B; Young, LT;
Indirizzi:
McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ci, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 65 - 74
SICI:
1461-1457(200103)4:1<65:IOMSGB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING ACTIVITY; INTRACELLULAR CALCIUM-CONCENTRATION; CHRONIC VALPROATE TREATMENT; ADENYLATE-CYCLASE ACTIVITY; RETICULUM STRESS PROTEINS; MESSENGER-RNA DISPLAY; RAT CEREBRAL-CORTEX; SACCHAROMYCES-CEREVISIAE; CHOLINERGIC STIMULATION; INCREASED EXPRESSION;
Keywords:
differential-display PCR; lithium; valproate; bipolar disorder; gene expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Young, LT 1200 Main St W,Room 4N77A, Hamilton, ON L8N 3Z5, Canada 1200 Main St W,Room 4N77A Hamilton ON Canada L8N 3Z5 Z5, Canada
Citazione:
J.F. Wang et al., "Identification of mood stabilizer-regulated genes by differential-display PCR", IN J NEUROP, 4(1), 2001, pp. 65-74

Abstract

An increasing body of evidence demonstrates that lithium and valproate have a regulatory effect on signal transduction pathways. Alteration of signalling molecules triggers changes in gene expression which are thought to contribute to the therapeutic effects of these drugs on bipolar disorder. Differential-display PCR was used to identify genes in rat cerebral cortex thatare regulated by chronic treatment with lithium and valproate. One novel lithium-regulated gene was identified and was characterized and studied further with 5'-RACE-PCR and library screening. We also found that valproate regulated the expression of the 78-kDa glucose-regulated protein (GW78). Chronic treatment with valproate has also been found to increase gene transcription, mRNA and protein levels of GRP78. These results suggest novel targetsfor lithium and valproate that may be relevant to their mechanism of action. The data further our understanding of the mechanism of the action of mood stabilizers, and help identify new targets for genetic studies and therapeutic strategies in bipolar disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:38:55