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Titolo:
Monoamine oxidases and tobacco smoking
Autore:
Berlin, I; Anthenelli, RM;
Indirizzi:
Pitie Salpetriere Univ Hosp, Dept Pharmacol, F-75013 Paris, France Pitie Salpetriere Univ Hosp Paris France F-75013 , F-75013 Paris, France Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA Med, Dept Psychiat, Cincinnati, OH USA Vet Affairs Med Ctr, Cincinnati, OH 45267 USA Vet Affairs Med Ctr Cincinnati OH USA 45267 Ctr, Cincinnati, OH 45267 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 33 - 42
SICI:
1461-1457(200103)4:1<33:MOATS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINED-RELEASE BUPROPION; CIGARETTE-SMOKE; HUMAN-PLATELET; MAO-B; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEUROTOXICITY; MENSTRUAL-CYCLE; ABUSE LIABILITY; DEFICIENT MICE; BRAIN; INHIBITION;
Keywords:
psychopharmacology of smoking; monoamine oxidase A; monoamine oxidase B; nicotine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Berlin, I Pitie Salpetriere Univ Hosp, Dept Pharmacol, 47 Bd Hop, F-75013 Paris, France Pitie Salpetriere Univ Hosp 47 Bd Hop Paris France F-75013 ance
Citazione:
I. Berlin e R.M. Anthenelli, "Monoamine oxidases and tobacco smoking", IN J NEUROP, 4(1), 2001, pp. 33-42

Abstract

Although nicotine has been identified as the main ingredient in tobacco responsible for aspects of the tobacco dependence syndrome, not all of the psychopharmacological effects of smoking can be explained by nicotine alone. Accumulating preclinical and clinical evidence has demonstrated that smoking also leads to potent inhibition of both types (A and B) of monoamine oxidase (MAO). Smokers have 30-40 % lower MAOB and 20-30% lower MAOA activity than non-smokers. Reduced MAO activity in smokers has been shown by direct measures (platelets, positron emission tomographic studies) or by indirect measures (concentration of monoamine catabolites in plasma or CSF). We examine the hypothesis that chronic habitual smoking can be better understood inthe context of two pharmacological factors: nicotine and reduced MAO activity. We speculate that MAO inhibition by compounds found in either tobacco or tobacco smoke can potentiate nicotine's effects. Based on this concept, more effective anti-smoking drug strategies may be developed. As a practical consequence of tobacco smoke's MAO-inhibitory properties, comparative psychiatric research studies need to screen and control for tobacco use.

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Documento generato il 23/01/20 alle ore 06:23:22