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Titolo:
Basal limbic system alteration in major depression: a hypothesis supportedby transcranial sonography and MRI findings
Autore:
Becker, G; Berg, D; Lesch, KP; Becker, T;
Indirizzi:
Univ Wurzburg, Dept Neurol, Neurol Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 l Klin, D-97080 Wurzburg, Germany Univ Leipzig, Psychiat Klin, Leipzig, Germany Univ Leipzig Leipzig Germany v Leipzig, Psychiat Klin, Leipzig, Germany Univ Wurzburg, Klin Psychiat & Psychotherapie, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 erapie, D-97070 Wurzburg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 21 - 31
SICI:
1461-1457(200103)4:1<21:BLSAIM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; REAL-TIME SONOGRAPHY; CEREBRAL BLOOD-FLOW; MAGNETIC-RESONANCE SPECTROSCOPY; POSITRON-EMISSION-TOMOGRAPHY; CSF MONOAMINE METABOLITES; BRAIN-STEM RAPHE; PARKINSONS-DISEASE; AFFECTIVE-DISORDERS; LOCUS-COERULEUS;
Keywords:
major depression; affective disorders; limbic system; Parkinson's disease; transcranial ultrasound;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, G Univ Wurzburg, Dept Neurol, Neurol Klin, Josef Schneider Str 11,D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080 y
Citazione:
G. Becker et al., "Basal limbic system alteration in major depression: a hypothesis supportedby transcranial sonography and MRI findings", IN J NEUROP, 4(1), 2001, pp. 21-31

Abstract

The pathogenesis of major depression (MD) remains unclear despite intensive research in the last decades which brought up a multitude of findings illustrating the complexity of this disorder. In this paper we will summarize the evidence pointing towards a structural alteration of the basal limbic system in MD and depression in Parkinson's disease (PD). Transcranial ultrasound and MRI studies in both depressive syndromes revealed altered signal intensity of the brainstem midline comprising fibre tracts of the basal limbic system. The hypothesis of a structural disruption of the basal limbic system is supported by biochemical and histopathological findings. The similarity of findings in MD and depression in PD might reflect a relationship between MD and neurodegenerative disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:00:04