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Titolo:
QT interval variability in panic disorder patients after isoproterenol infusions
Autore:
Pohl, R; Yeragani, VK;
Indirizzi:
Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48207 USA Wayne State Univ Detroit MI USA 48207 hav Neurosci, Detroit, MI 48207 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 17 - 20
SICI:
1461-1457(200103)4:1<17:QIVIPD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; POWER-SPECTRAL-ANALYSIS; SUDDEN CARDIAC DEATH; PHOBIC ANXIETY; AUTONOMIC CHARACTERISTICS; REPOLARIZATION LABILITY; BLOOD-PRESSURE; DISEASE; SYMPTOMS; STRESS;
Keywords:
isoproterenol; QT interval variability; panic disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pohl, R Wayne State Univ, Dept Psychiat & Behav Neurosci, 2751 E Jefferson,Suite 200, Detroit, MI 48207 USA Wayne State Univ 2751 E Jefferson,Suite 200 Detroit MI USA 48207 A
Citazione:
R. Pohl e V.K. Yeragani, "QT interval variability in panic disorder patients after isoproterenol infusions", IN J NEUROP, 4(1), 2001, pp. 17-20

Abstract

Anxiety symptoms are associated with a marked increase in sudden cardiac death, suggesting an abnormality in the autonomic control of the heart. We examined the effects of sympathetic stimulation on QT interval variability in panic disorder patients by infusing the P-adrenergic agonist isoproterenol in 6 panic disorder patients and II normal subjects. The ECG signal was analysed before the infusion and after 5 min after the infusion was started. The outcome measures were the QT variability normalized for mean QT interval (QTvm) and the QT variability index (QTvi), a measure of QT variability normalized by the concomitant heart rate variability. Patients with panic disorder had more variability in QT interval duration than normal controls and this variability was increased further by sympathetic stimulation with isoproterenol. The isoproferenol-associated increase in QT interval occurredin controls in the absence of significant anxiety. However, on one of two measures, the increase in QT interval variability was greater in patients with panic disorder, suggesting a greater sensitivity to isoproterenol or toisoproterenol-induced anxiety.

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Documento generato il 30/03/20 alle ore 17:44:12