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Titolo:
Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats
Autore:
Borsini, F; Brambilla, A; Cesana, R; Grippa, N;
Indirizzi:
Boehringer Ingelheim Pharma KG, CNS Dept, D-88398 Biberach, Germany Boehringer Ingelheim Pharma KG Biberach Germany D-88398 iberach, Germany Boehringer Ingelheim Italia, I-20139 Milan, Italy Boehringer Ingelheim Italia Milan Italy I-20139 ia, I-20139 Milan, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 9 - 15
SICI:
1461-1457(200103)4:1<9:LOIBFA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT RECEPTOR SUBPOPULATIONS; MONOAMINE-OXIDASE INHIBITOR; IN-VIVO; PHARMACOLOGICAL PROFILE; MOCLOBEMIDE-FLUOXETINE; BEHAVIORAL EVIDENCE; ANTAGONIST; BIMT-17; AGONIST; BRAIN;
Keywords:
flibanserin; antidepressants; 5-HT syndrome; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Borsini, F Boehringer Ingelheim Pharma KG, CNS Dept, Bldg J63,BirkendorferStr 65, D-88398 Biberach, Germany Boehringer Ingelheim Pharma KG Bldg J63,Birkendorfer Str 65 Biberach Germany D-88398
Citazione:
F. Borsini et al., "Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats", IN J NEUROP, 4(1), 2001, pp. 9-15

Abstract

This study was aimed at evaluating the ability of fibanserin, a 5-HT1A receptor full agonist with antidepressant potential, to induce the 5-HT syndrome (flat body posture, hindlimb abduction and forepaw treading) in rats previously administered with clinically active antidepressants imipramine, fluoxetine or paroxetine. The 5-HT syndrome was observed for 50 min after intraperitoneal administration of flibanserin (0, 8 or 64 mg/kg) given 10 min after antidepressants (0 or 15 mg/kg). Flibanserin induced flat body postureand very slight hindlimb abduction only at 64 mg/kg. No dose of flibanserin elicited forepaw treading. Similar but milder symptoms were induced by antidepressants. No interaction between flibanserin and antidepressants was observed. A dose of 10 mg/kg flibanserin did not change the flat body posture induced by 8 mg/kg (+/-)-8-OH-DPAT but antagonized (+/-)-8-OH-DPAT-induced forepaw treading.

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Documento generato il 25/01/20 alle ore 16:38:42