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Titolo:
Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice
Autore:
McAllister-Williams, RH; Anderson, AJ; Young, AH;
Indirizzi:
Univ Newcastle Upon Tyne, Royal Victoria Infirm, Sch Neurosci & Psychiat, Dept Psychiat, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE1 4LP Royal Coll Glasgow, Strathclyde Inst Drug Res, Glasgow, Lanark, Scotland Royal Coll Glasgow Glasgow Lanark Scotland es, Glasgow, Lanark, Scotland
Titolo Testata:
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 4, anno: 2001,
pagine: 1 - 8
SICI:
1461-1457(200103)4:1<1:CSA8HI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESS-INDUCED HYPERTHERMIA; DORSAL RAPHE NUCLEUS; 8-OH-DPAT-INDUCED HYPOTHERMIA; BODY-TEMPERATURE; DEPRESSION; RESPONSES; THERMOREGULATION; SEROTONIN; ANXIETY; MODEL;
Keywords:
mice; thermoregulation; corticosteroids; 5-HT1A receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: McAllister-Williams, RH Univ Newcastle Upon Tyne, Royal Victoria Infirm, Sch Neurosci & Psychiat, Dept Psychiat, Leazes Wing, Newcastle Upon Tyne NE14LP, Tyne & Wear, England Univ Newcastle Upon Tyne Leazes Wing Newcastle Upon Tyne Tyne & Wear England NE1 4LP
Citazione:
R.H. McAllister-Williams et al., "Corticosterone selectively attenuates 8-OH-DPAT-mediated hypothermia in mice", IN J NEUROP, 4(1), 2001, pp. 1-8

Abstract

The 5-HT1A agonist 8-OH-DPAT produces a hypothermia in mice mediated by somatodendritic 5-HT1A receptors, that is attenuated by antidepressants and corticosterone. The present study investigated if the effect of corticosterone is specific to the serotonergic system or a non-specific effect on thermoregulation. Administration of corticosterone for 3 d had no effect on dopaminergic (apomorphine) or adrenergic (clonidine) hypothermic challenges. However in addition to 8-OH-DPAT, nicotine-induced hypothermia was attenuatedby corticosterone. Administration of the selective nicotinic antagonist mecamylamine had no effect on 8-OH-DPAT-induced hypothermia, although nicotine-induced hypothermia was attenuated by the selective 5-HT1A antagonist WAY-100635. This demonstrates a serotonergic-nicotinic interaction in the generation of hypothermia in mice and is consistent with corticosterone selectively attenuating somatodendritic 5-HT1A receptor function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:59:00