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Titolo:
Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS
Autore:
Weinmann, W; Bohnert, M; Wiedemann, A; Renz, M; Lehmann, N; Pollak, S;
Indirizzi:
Univ Freiburg, Inst Legal Med, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 al Med, D-79104 Freiburg, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
fascicolo: 4-5, volume: 114, anno: 2001,
pagine: 252 - 258
SICI:
0937-9827(200104)114:4-5<252:PDAIOS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE DYSFUNCTION; EFFICACY; SAFETY; CITRATE; EXTRACTION; DISEASE; DRUGS;
Keywords:
sildenafil; Viagra; tandem mass spectrometry; electrospray ionisation; cardiac failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Weinmann, W Univ Freiburg, Inst Legal Med, Albertstr 9, D-79104 Freiburg, Germany Univ Freiburg Albertstr 9 Freiburg Germany D-79104 g, Germany
Citazione:
W. Weinmann et al., "Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS", INT J LEGAL, 114(4-5), 2001, pp. 252-258

Abstract

The highly putrefied corpse of an 80-year-old man was found in the apartment which he had rented to a prostitute. A package of Viagra 25 was found beside the corpse and three tablets were missing. Autopsy revealed severe coronary artery sclerosis as well as signs of previous myocardial infarctions. For the detection and identification of sildenafil and three metabolites in urine and tissue samples, solid-phase extraction, LC/MS and MS/MS methodswere developed. Blood was not available for toxicological analysis due to the putrefaction. For method development, urine from a volunteer who had ingested 25 mg sildenafil was collected over 8 h, and three metabolites were identified by MS/MS. These metabolites were also found in the victim's urine. These findings prove that sildenafil was taken some time prior to death,but the causality of sildenafil intake and fatal cardiac failure could notbe proven, since no blood was available for analysis. However, the administration of sildenafil was contraindicated due to several previous myocardial infarctions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:59:51