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Titolo:
Gangliosides derived from a T cell lymphoma inhibit bone marrow cell proliferation and differentiation
Autore:
Bharti, AC; Singh, SM;
Indirizzi:
Banaras Hindu Univ, Sch Biotechnol, Varanasi 221005, Uttar Pradesh, India Banaras Hindu Univ Varanasi Uttar Pradesh India 221005 tar Pradesh, India
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 1, volume: 1, anno: 2001,
pagine: 155 - 165
SICI:
1567-5769(200101)1:1<155:GDFATC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE PERITONEAL-MACROPHAGES; COLONY-STIMULATING FACTOR; TUMOR-BEARING MICE; IN-VIVO; IMMUNE-RESPONSE; MODULATION; GROWTH; CANCER; IMMUNOSUPPRESSION; HEMATOPOIESIS;
Keywords:
Dalton's lymphoma; gangliosides; bone marrow; hematopoiesis; immunosuppression; myeloid differentiation; lymphocyte proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, SM Banaras Hindu Univ, Sch Biotechnol, Varanasi 221005, Uttar Pradesh, India Banaras Hindu Univ Varanasi Uttar Pradesh India 221005 h, India
Citazione:
A.C. Bharti e S.M. Singh, "Gangliosides derived from a T cell lymphoma inhibit bone marrow cell proliferation and differentiation", INT IMMUNO, 1(1), 2001, pp. 155-165

Abstract

Previously, we have observed a modulation in the hone marrow; hematopoiesis and alteration in the repertoire of blood monocytes and lymphocytes in mice bearing a spontaneous T cell lymphoma, designated as Dalton's lymphoma (DL). In the present investigation, we show that in vivo or in vitro treatment of bone marrow cells (BMC) with gangliosides of DL (DLG) results in inhibition of proliferative ability and alteration of colony-forming ability (CFA) of BMC. BMC incubated with DLG also showed a decrease in cell viabilityin a concentration-dependent manner. BMC colony-forming assays in the presence of macrophage-colony-stimulating factor (M-CSF) showed a dose-dependent decrease in the number of colonies with a concomitant decrease in macrophage- and granulocyte macrophage-colony-forming units (CFU-M and CFU-GM, respectively) and an increase in granulocyte-CFU (CFU-G). Neuraminidase treatment of DLG abrogated their inhibitory action on BMC. Further, antibodies toG(D3) and to lesser extent G(M2) neutralized the inhibitory effect of DLG on BMC. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:46:30