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Titolo:
Induction of tumor necrosis factor-alpha in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide
Autore:
Ueda, H; Yamazaki, M;
Indirizzi:
Teikyo Univ, Fac Pharmaceut Sci, Dept Med Chem, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 ept Med Chem, Kanagawa 1990195, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 1, volume: 1, anno: 2001,
pagine: 97 - 104
SICI:
1567-5769(200101)1:1<97:IOTNFI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSPECIFIC RESISTANCE; ADJUVANT ACTIVITY; MACROPHAGES; MDP-LYS(L18); MICE; AUGMENTATION; STIMULATION; INFECTIONS; ACTIVATION; CYTOKINES;
Keywords:
romurtide; oral; tumor necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Yamazaki, M Teikyo Univ, Fac Pharmaceut Sci, Dept Med Chem, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 , Kanagawa 1990195, Japan
Citazione:
H. Ueda e M. Yamazaki, "Induction of tumor necrosis factor-alpha in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide", INT IMMUNO, 1(1), 2001, pp. 97-104

Abstract

The novel applications of a muramyl dipeptide analogue, romurtide, were investigated. When mice were intravenously injected with 10-1000 mug/mouse ofromurtide as a primer and 3 KE/mouse of OK-432 as a trigger, systemic tumor necrosis factor-alpha (TNF-alpha) activity was increased. Similar effectswere also detected by oral administration of romurtide at 1000 to 10,000 mug/mouse. These effects reached maximum at 3 h (intravenous injection, i.v.) or 6 h (oral administration, p.o.) after administration and were sustained for 48 h. When romurtide was administered to MM46 tumor-bearing mice orally, the significant augmentation of TNF-alpha production could be detected in the: solid tumor and the liver. When romurtide was intravenously injected to the rumor bearer, the TNF-alpha production was significantly augmentedin the spleen. These findings suggest that romurtide can augment the host defense system by both the parenteral and oral route, and indicate the possibility of a new type of anti-tumor therapy to induce TNF-alpha in the tumor region. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 07:19:58