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Titolo:
In vivo modulation of the distribution of thymocyte subsets by female sex steroid hormones
Autore:
Leposavic, G; Obradovic, S; Kosec, D; Pejcic-Karapetrovic, B; Vidic-Dankovic, B;
Indirizzi:
Fac Pharm, Dept Physiol, YU-11221 Belgrade, Yugoslavia Fac Pharm Belgrade Yugoslavia YU-11221 ol, YU-11221 Belgrade, Yugoslavia
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 1, volume: 1, anno: 2001,
pagine: 1 - 12
SICI:
1567-5769(200101)1:1<1:IVMOTD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; RAT THYMUS; T-CELLS; PROGESTIN RECEPTOR; POSITIVE SELECTION; LYMPHOID-CELLS; LYMPHOCYTES-T; ESTROGEN; MICE; GONADECTOMY;
Keywords:
estrogens; progesterone; ovariectomy; rat thymus; T-cell maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Leposavic, G Fac Pharm, Dept Physiol, 450 Vojvode Stepe, YU-11221 Belgrade, Yugoslavia Fac Pharm 450 Vojvode Stepe Belgrade Yugoslavia YU-11221 via
Citazione:
G. Leposavic et al., "In vivo modulation of the distribution of thymocyte subsets by female sex steroid hormones", INT IMMUNO, 1(1), 2001, pp. 1-12

Abstract

This study examined the effects of the principal ovarian steroids, 17 beta-estradiol (E) and progesterone (P), on the thymic structure and on the intrathymic development of T-cells. Adult female rats were ovariectomized (OVX) and treated for 13 days with physiological doses of either E or P; controls received an equivalent volume of vehicle. Ovariectomy produced a markedincrease (vs, sham-operated controls) in thymus weight, which was associated with an increase in the volume and cellularity of both the medulla and cortex. Treatment of OVX rats with E reduced the thymic weight to value, which was significantly lower than that of sham-operated controls decreasing the volume of cortex below level in sham-OVX rats, and reversing the effect of ovariectomy on the volume of medulla. P only prevented the increases in thymus weight and cortical volume induced by OVX. However, unlike E, it hadno discernable effect on the medullary volume. E treatment reduced the cellularity of the cortex and medulla to values, which were lower than those of sham-OVX rats, while P only reversed the effects of OVX on the cellularity of both the compartments. Ovariectomy also had a profound effect on the thymocyte profile, increasing the proportion of CD4(+)8(+)TCR alpha beta (-)cells and producing a corresponding decrease in the relative proportions of all TCR alpha beta (high) cell subsets. The decrease in the latter was opposed by treatment with E or P. However, the sensitivity of the less maturecells (except CD4(-)8(-)TCR alpha beta (-), the percentage of which was reduced by both hormones) to the two hormones differed. E reduced the relative proportion of CD4(-)8(+)TCR alpha beta (-), CD4(-)8(+)TCR alpha beta (low) and CD4(+) 8(+)TCR alpha beta (-) cells, while P increased the percentageof CD4(-) 8 +TCR alpha beta (low) cells. The results suggest that E anti P affect both the lymphoid and nonlymphoidcompartments of the thymus, and that while P increases the volume of the nonlymphoid component of the medulla, E has the opposite effect. The findingthat ovariectomy decreased while E and P increased the relative proportionof the most mature thymocytes, which include CD4(-)8(-)TCR alpha beta (high) cells that are believed to harbour potentially autoreactive cell clones,is particularly interesting and may relate to the high propensity of autoimmune diseases in females. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:20:17