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Titolo:
Pyrrolidine dithiocarbamate inhibits serum-induced NF-kappa B activation and induces apoptosis in ROS 17/2.8 osteoblasts
Autore:
Chae, H; Chae, S; Park, N; Bang, B; Cho, S; Kim, J; Kim, H; Kim, H; Lee, Z; Kim, H;
Indirizzi:
Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Chonbuk Natl Univ, Sch Med, Dept Pharmacol, Chonju, South Korea Chonbuk Natl Univ Chonju South Korea ept Pharmacol, Chonju, South Korea Chonbuk Natl Univ, Sch Med, Inst Cardiovasc Res, Chonju, South Korea Chonbuk Natl Univ Chonju South Korea ardiovasc Res, Chonju, South Korea Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan, Chonbuk 570749, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 honbuk 570749, South Korea Chosun Univ, Natl Res Lab Bone Metab, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 etab, Kwangju 501759, South Korea Chosun Univ, Res Ctr Proteinous Mat, Kwangju 501759, South Korea Chosun Univ Kwangju South Korea 501759 Mat, Kwangju 501759, South Korea
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 255 - 263
SICI:
1567-5769(200102)1:2<255:PDISNB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CELL-DEATH; SIGNAL-TRANSDUCTION; TRANSCRIPTION FACTOR; SURVIVAL PATHWAY; JUN; DOMAIN; INVOLVEMENT; BINDS; HIV-1;
Keywords:
PDTC; osteoblast; apoptois; MAPK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, H Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 Chonbuk, SouthKorea
Citazione:
H. Chae et al., "Pyrrolidine dithiocarbamate inhibits serum-induced NF-kappa B activation and induces apoptosis in ROS 17/2.8 osteoblasts", INT IMMUNO, 1(2), 2001, pp. 255-263

Abstract

Nuclear factor-kappaB (NF-kappaB) activity affects cell survival in ROS 17/2.8 osteoblasts. Preventing NF-kappaB transcription activity with a potentNF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), results in apoptosis. Thus, we explored the effect of pyrrolidine dithiocarbamate (PDTC), which potently blocks the activation of nuclear factor-kappaB (NF-kappaB) in serum-exposed condition, on the activation of mitogen activated protein kinase (MAPK), especially, JNK/SAPK and p38 MAPK induction. PDTC transiently increased the phosphotransferase activity of c-Jun N-terminal Kinase1 (JNK1), which might in turn activates transcriptional activity of activating protein-1 (AP-1). The activation of JNK was completely decreased in dominant negative JNK1 transfected cells and the PDTC-induced cell death was attenuated in these cells. In addition, AP-1 activation was decreased in the JNK 1 transfected cells, compared with vector-transfected cells. The NF-KB inhibitor also transiently activates p38 MAPK but SB203580, a specific p38 MAPK inhibitor, does not have any regulatory effect on PDTC-induced cell death, suggesting that the cell death is mediated by JNK not by p38 MAPK. Thus, overall, these results show that PDTC induces apoptosis and suggest that JNK/SAPK and subsequent AP-1 activation may be involved in the apoptotic pathway in ROS 17/2.8 osteoblasts. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/02/20 alle ore 14:25:04