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Titolo:
Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages
Autore:
Jeon, YJ; Han, SB; Lee, SH; Kim, HC; Ahn, KS; Kim, HM;
Indirizzi:
Korea Res Inst Biosci & Biotechnol, KRIBB, Taejon 305600, South Korea Korea Res Inst Biosci & Biotechnol Taejon South Korea 305600 South Korea Korea Adv Inst Sci & Technol, Dept Sci Biol, Taejon 305701, South Korea Korea Adv Inst Sci & Technol Taejon South Korea 305701 5701, South Korea
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 237 - 245
SICI:
1567-5769(200102)1:2<237:AOMPKP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; EXPRESSION; P38; INHIBITOR; INDUCTION; BINDING; ALPHA; CD14;
Keywords:
Angelica gigas Nakai; angelan; macrophage; PTK; p38;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM Korea Res Inst Biosci & Biotechnol, KRIBB, POB 115, Taejon 305600,South Korea Korea Res Inst Biosci & Biotechnol POB 115 Taejon South Korea305600
Citazione:
Y.J. Jeon et al., "Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages", INT IMMUNO, 1(2), 2001, pp. 237-245

Abstract

In our previous studies, we showed that angelan. a polysaccharide purifiedfrom Angelica gigas Nakai, specifically activated macrophages to induce cytokines including inducible nitric oxide synthase (iNOS) which has strong anti-tumor activities [Immunopharmacology, 1999; 43: 1.]. In the present study, we investigated the intracellular signal transduction pathways involvedin the angelan-induced iNOS synthesis by murine macrophages. Protein tyrosine phosphorylation was induced within 5 min by angelan, and the blocking of protein tyrosine kinases (PTKs) inhibited down-stream pathways leading toiNOS production in response to angelan. Treament df RAW 264.7 cells with angelan resulted in significant activation of extracellular signal-regulatedkinase 1 and 2 (ERK1/2) and p38, while stress-activated protein kinase/c-Jun NH2 terminal kinase (SAPK/JNK) was not activated by angelan, The specific p38 inhibitor SB203580 abrogated the angelan-induced iNOS synthesis, whereas the selective mitogen-activated protein kinase (MAPK)/extracellular signar-regulated kinase 1 (MEK-1) inhibitor PD98059 did not affect the iNOS induction. In conclusion, we demonstrate that PTK and p38 MAPK activation arerequired to transduce signals leading to iNOS expression in angelan-stimulated murine macrophages. (C) 2001 Elsel ier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:56:58