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Titolo:
Quinolones alter defense reactions mediated by macrophages
Autore:
Azuma, Y; Shinohara, M; Wang, PL; Ohura, K;
Indirizzi:
Osaka Dent Univ, Dept Pharmacol, Hirakata, Osaka 5731121, Japan Osaka DentUniv Hirakata Osaka Japan 5731121 rakata, Osaka 5731121, Japan
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 2, volume: 1, anno: 2001,
pagine: 179 - 187
SICI:
1567-5769(200102)1:2<179:QADRMB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; NEUTROPHIL NADPH-OXIDASE; TISSUE-CULTURE CELLS; PROTEIN-KINASE-C; INTRACELLULAR ACTIVITY; PHAGOCYTIC-CELLS; IMMUNE FUNCTIONS; IN-VITRO; ACTIVATION; CIPROFLOXACIN;
Keywords:
quinolones; macrophage; phagocytosis; adhesion; hydrogen peroxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Azuma, Y Osaka Dent Univ, Dept Pharmacol, 8-1 Kuzuhahanazono Cho, Hirakata, Osaka 5731121, Japan Osaka Dent Univ 8-1 Kuzuhahanazono Cho Hirakata Osaka Japan 5731121
Citazione:
Y. Azuma et al., "Quinolones alter defense reactions mediated by macrophages", INT IMMUNO, 1(2), 2001, pp. 179-187

Abstract

The innate host defense system is regulated in part by the number and activation of the function of neutrophils and macrophages. The immunological effects of a variety of quinolones on host defense functions of macrophage are reported. Ofloxacin (OFLX), lomefloxacin (LFLX), tosufloxacin (TFLX), fleroxacin (FLRX), sparfloxacin (SPFX) and levofloxacin (LVFX) significantly inhibited phagocytosis of Escherichia coli by macrophages. Moreover, TFLX markedly potentiated tile expression of the adhesion molecule Mac-1 by macrophages. No significant alteration was detected in the adherence and the expression of adhesion molecule Mac-1 in macrophages treated with the other quinolones. In contrast, OFLX, LFLX, TFLX, and LVFX were effective in significantly increasing the production of hydrogen peroxide. while the other agents did not. These results suggest that the quinolones at a therapeutic concentration differentially affect phagocytosis, adhesion. and the production of hydrogen peroxide by macrophages. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:30:46