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Titolo:
Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR
Autore:
Kren, V; Qi, NN; Krenova, D; Zidek, V; Sladka, M; Jachymova, M; Mikova, B; Horky, K; Bonne, A; Van Lith, HA; Van Zutphen, BFM; Lau, YFC; Pravenec, M; St Lezin, E;
Indirizzi:
Charles Univ, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic Charles Univ Prague Czech Republic & Med Genet, Prague, Czech Republic Charles Univ, Fac Med 1, Gen Fac Hosp, Prague, Czech Republic Charles Univ Prague Czech Republic Gen Fac Hosp, Prague, Czech Republic Acad Sci Czech Republ, Inst Physiol, CR-11142 Prague, Czech Republic Acad Sci Czech Republ Prague Czech Republic CR-11142 gue, Czech Republic Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA Univ CalifSan Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Utrecht, Fac Vet, Dept Lab Anim Sci, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands ept Lab Anim Sci, Utrecht, Netherlands
Titolo Testata:
HYPERTENSION
fascicolo: 4, volume: 37, anno: 2001,
pagine: 1147 - 1152
SICI:
0194-911X(200104)37:4<1147:YTICIB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RAT; QUANTITATIVE TRAIT LOCI; RECOMBINANT INBRED STRAINS; WISTAR-KYOTO RATS; INSULIN-RESISTANCE; SEX-CHROMOSOMES; PLASMA-INSULIN; FATTY-ACID; GLUCOSE; HYPERINSULINEMIA;
Keywords:
hypertension, genetic; rats, spontaneously hypertensive; cholesterol; genes; lipids; cardiovascular disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: St Lezin, E San Francisco VA Med Ctr 113A, Dept Lab Med, 4150 Clement St, San Francisco, CA 94121 USA San Francisco VA Med Ctr 113A 4150 Clement St San Francisco CA USA 94121
Citazione:
V. Kren et al., "Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR", HYPERTENSIO, 37(4), 2001, pp. 1147-1152

Abstract

Previous studies with chromosome-Y consomic strains of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats suggest that a quantitative trait locus for blood pressure regulation exists on chromosome Y. To test this hypothesis in the SHR-Brown Norway (BN) model and to study the effects of chromosome Y on lipid and carbohydrate metabolism, we produced a new consomic strain of SHR carrying the Y chromosome transferred from the BN rat. We found that replacing, the SHR Y chromosome with the BN Y chromosome resulted in significant decreases in systolic and diastolic blood pressures in the SHR.BN-Y consomic strain (P <0.05). To elicit possible dietary-induced variation in lipid and glucose metabolism between the SHR progenitor and chromosome-Y consomic strains, we fed rats a high-fructose diet for 15 days in addition to the normal diet. On the high-fructose diet, the SHR.BN-Y consomic rats exhibited significantly increased levels of serum triglycerides and decreased levels of serum HDL cholesterol versus the SHR progenitor rats. Glucose tolerance and insulin/glucose ratios, however, were similar in both strains on both normal and high-fructose diets. These findings provide direct evidence that a gene or genes on chromosome Y contribute to the pathogenesis of spontaneous hypertension in the SHR-BN model. These results also indicate that transfer of the Y chromosome from the BN rat onto the SHR background exacerbates dietary-induced dyslipidemia in SHR. Thus, genetic variationin genes on the Y chromosome may contribute to variation in blood pressureand lipid levels and may influence the risk for cardiovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:05:20