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Titolo:
The association between risk factors for tardive dyskinesia and phenylalanine-induced abnormal movements in schizophrenia
Autore:
Schultz, SK; Ellingrod, V; Fleming, FW; Andreasen, NC;
Indirizzi:
Univ Iowa, Coll Med, Mental Htlh Clin Res Ctr, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 lh Clin Res Ctr, Iowa City, IA 52242 USA Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa, Dept Pharm, Iowa City, IA USA Univ Iowa Iowa City IA USAUniv Iowa, Dept Pharm, Iowa City, IA USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 16, anno: 2001,
pagine: 273 - 277
SICI:
0885-6222(200104)16:3<273:TABRFF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACIDS;
Keywords:
phenylalanine; schizophrenia; tardive dyskinesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Schultz, SK Univ Iowa, Coll Med, Mental Htlh Clin Res Ctr, 1-189A MEB, Iowa City, IA 52242 USA Univ Iowa 1-189A MEB Iowa City IA USA 52242 City, IA 52242 USA
Citazione:
S.K. Schultz et al., "The association between risk factors for tardive dyskinesia and phenylalanine-induced abnormal movements in schizophrenia", HUM PSYCHOP, 16(3), 2001, pp. 273-277

Abstract

We examined whether an oral challenge dose of the amino acid phenylalanine(a dopamine precursor) exacerbates the abnormal movements of tardive dyskinesia (TD). We also examined age, gender, treatment duration, and baseline movement severity in relation to phenylalanine-induced changes in movements. Lastly, we assessed the influence of fasting amino acid levels on phenylalanine-induced movements, In a placebo-controlled fashion, the abnormal involuntary movement scale (AIMS) was obtained on 25 patients before and aftera phenylalanine challenge drink. A general linear model determined the relative effects of age, gender, treatment duration, and fasting amino acid levels on the magnitude of induced movements. Age and treatment duration did not affect phenylalanine-induced movements. Lower fasting levels of phenylalanine were associated with greater movements after controlling for age, F = 11.89, p < 0.003. The severity of abnormal movements at baseline also predicted response to phenylalanine, F = 8.62, p = 0.0079. Brain amino acid and neurotransmitter pools are influenced by changes in dietary protein, which may have implications in the development and prevention of movement disorders. This study suggests that fasting amino acid levels may predict differences in vulnerability to movements during an influx of neurotransmitter precursors, perhaps due to long-term compensatory changes in receptor sensitivity. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:01:28