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Titolo:
A pilot, open clinical study of depakote in the treatment of cocaine abuse
Autore:
Halikas, JA; Center, BA; Pearson, VL; Carlson, GA; Crea, F;
Indirizzi:
Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ychiat, Minneapolis, MN 55455 USA Univ Minnesota, Dept Family Practice, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA t Family Practice, Minneapolis, MN USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 16, anno: 2001,
pagine: 257 - 264
SICI:
0885-6222(200104)16:3<257:APOCSO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPULSE CONTROL DISORDERS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; CARBAMAZEPINE; DEPENDENCE; BROMOCRIPTINE; WITHDRAWAL; VALPROATE;
Keywords:
cocaine abuse; serum valproic acid level; cocaine treatment; relapse prevention; divalproex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Halikas, JA 2335 N Tamiami Trail,Suite 205,Moorings Profess B, Naples, FL 34103 USA 2335 N Tamiami Trail,Suite 205,Moorings Profess B Naples FL USA 34103
Citazione:
J.A. Halikas et al., "A pilot, open clinical study of depakote in the treatment of cocaine abuse", HUM PSYCHOP, 16(3), 2001, pp. 257-264

Abstract

The effectiveness of increasing levels of valproic acid on cocaine abstinence was evaluated in an open-label trial of 55 subjects. Significantly lower percentages of individuals with valproate serum levels above 50 mcg/ml reported cocaine use and had less positive urinalyses as compared to those with serum levels less than 50 mcg/ml. The total number of days of cocaine use decreased significantly (p < 0.001) and improved levels of subject functioning were found with increasing serum levels of valproic acid. This pilot study offers confirmation that the divalproex sodium form of valproic acid,when used in sufficient serum levels, may provide an effective pharmacologic adjunct in the management and treatment of cocaine dependency. Copyright(C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:02:05