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Titolo:
The platelet as a peripheral marker in psychiatric illness
Autore:
Plein, H; Berk, M;
Indirizzi:
Univ Witwatersrand, Fac Hlth Sci, Dept Expt & Clin Pharmacol, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa Univ Witwatersrand, Fac Hlth Sci, Dept Psychiat, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 16, anno: 2001,
pagine: 229 - 236
SICI:
0885-6222(200104)16:3<229:TPAAPM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM RESPONSE; 5-HT2 RECEPTOR-BINDING; ACUTE MYOCARDIAL-INFARCTION; PANIC DISORDER PATIENTS; MAJOR DEPRESSION; IMIPRAMINE BINDING; BLOOD-PLATELETS; SUBSYNDROMAL DEPRESSION; SCHIZOPHRENIC-PATIENTS; ESSENTIAL-HYPERTENSION;
Keywords:
cardiovascular mortality; intracellular calcium response; major depression; peripheral markers; platelet; psychiatric illness; psychotic illness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Witwatersrand, Fac Hlth Sci, Dept Psychiat, 7 York Rd, ZA-2193 Johannesburg, South Africa Univ Witwatersrand 7 York Rd Johannesburg South Africa ZA-2193 ca
Citazione:
H. Plein e M. Berk, "The platelet as a peripheral marker in psychiatric illness", HUM PSYCHOP, 16(3), 2001, pp. 229-236

Abstract

The identification of peripheral markers of psychiatric illness is important if an improvement in the diagnosis and treatment of various diseases with overlapping symptomatology is desired. There are many disorders that not only have overlapping symptomatology. but also have similar biological disturbances. The functional capability of the neurons involved in the disease processes may be at the crux of the underlying pathology. The platelet intracellular calcium response to neurotransmitter stimulation has previously been used as a peripheral marker of psychiatric illness. This review discusses evidence in support of the extended use of the platelet as a peripheral marker. The use of the platelet intracellular calcium response to neurotransmitter stimulation as a state or trait marker in major depression, the specificity and selectivity of this response, and the possible use of the platelet as a peripheral marker in psychotic disorders such as schizophrenia, mania and psychotic depression are shown. Finally, a proposed mechanism for the association between certain psychiatric disorders and cardiovascular disease is discussed. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:26:33