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Titolo:
Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression: an international, 6-week double-blind study
Autore:
Lepine, JP; Altamura, C; Ansseau, M; Gutierrez, JLA; Bitter, I; Lader, M; Waintraub, L;
Indirizzi:
Ctr Hosp Paul Brousse, Psychiat Serv, F-94804 Villejuif, France Ctr Hosp Paul Brousse Villejuif France F-94804 F-94804 Villejuif, France Hop Fernand Widal, Psychiat Serv, F-75745 Paris 10, France Hop Fernand Widal Paris France 10 sychiat Serv, F-75745 Paris 10, France Univ Milan, Cattedra Psichiatria, Osped L Sacco, I-20157 Milan, Italy UnivMilan Milan Italy I-20157 tria, Osped L Sacco, I-20157 Milan, Italy CHU Sart Tilman, Psychiat Serv, B-4000 Liege 1, Belgium CHU Sart Tilman Liege Belgium 1 , Psychiat Serv, B-4000 Liege 1, Belgium Hosp Clin San Carlos, Serv Psiquiatria, Madrid 28040, Spain Hosp Clin San Carlos Madrid Spain 28040 Psiquiatria, Madrid 28040, Spain Semmelweis Univ Med, Dept Psychiat & Psychotherapy, H-1083 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1083 py, H-1083 Budapest, Hungary Inst Psychiat, Clin Pharmacol Sect, London SE5 8AF, England Inst PsychiatLondon England SE5 8AF macol Sect, London SE5 8AF, England
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 3, volume: 16, anno: 2001,
pagine: 219 - 227
SICI:
0885-6222(200104)16:3<219:TAPIMD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATIONAL-COMORBIDITY-SURVEY; TRIPARTITE MODEL; ANXIETY; AMITRIPTYLINE; EPISODES; EFFICACY; VALIDITY; PLACEBO; SCALES; TRIAL;
Keywords:
anxious symptoms; major depressive disorder; paroxetine; tianeptine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Waintraub, L Ctr Hosp Paul Brousse, Psychiat Serv, 12 Ave Paul Vaillant Couturier, F-94804 Villejuif, France Ctr Hosp Paul Brousse 12 Ave Paul Vaillant Couturier Villejuif France F-94804
Citazione:
J.P. Lepine et al., "Tianeptine and paroxetine in major depressive disorder, with a special focus on the anxious component in depression: an international, 6-week double-blind study", HUM PSYCHOP, 16(3), 2001, pp. 219-227

Abstract

Tianeptine (37.5 mg/day) and paroxetine (20 mg/day) were compared in a population of depressive patients without past or current history of co-morbidanxiety and/or important anxiolytic treatment. In a 6-week, double blind trial, the special focus was on anxious symptoms. Both drugs showed good efficacy on depressive symptomatology, assessed with MADRS and HDRS, but no difference was detected between tianeptine and paroxetine, for any assessment criterion. Despite the choice of selected depressive patients, without any co-morbid anxious disorder. anxiety scale scores at inclusion (HAMA and BAS) were appreciable bur correlated poorly with depressive scores. Both tianeptine and paroxetine improved the apparent anxious component in depression. Tolerability of both drugs was good, although significantly better with tianeptine. Thus tianeptine and paroxetine are effective and safe treatments for majordepression and may also act directly on the anxious component of the psychopathology. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:39:01