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Titolo:
A new immunodeficient mouse model for human myoblast transplantation
Autore:
Cooper, RN; Irintchev, A; Di Santo, JP; Zweyer, M; Morgan, JE; Partridge, TA; Butler-Browne, GS; Mouly, V; Wernig, A;
Indirizzi:
Hop La Pitie Salpetriere, CNRS, UMR 700, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 700, F-75013 Paris, France Univ Bonn, Dept Physiol & Neurophysiol, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 iol & Neurophysiol, D-53111 Bonn, Germany Inst Pasteur, Dept Immunol, Unite Cytokines & Dev Lymphoide, F-75724 Paris, France Inst Pasteur Paris France F-75724 & Dev Lymphoide, F-75724 Paris, France Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med, MRC Clin Sci Ctr, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
HUMAN GENE THERAPY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 823 - 831
SICI:
1043-0342(200105)12:7<823:ANIMMF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-GAMMA CHAIN; MYOGENIC CELLS; SKELETAL-MUSCLE; MDX MOUSE; SCID MICE; EXPRESSION; REGENERATION; IMPLANTATION; ENGRAFTMENT; PATTERN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Butler-Browne, GS Hop La Pitie Salpetriere, CNRS, UMR 700, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 , France
Citazione:
R.N. Cooper et al., "A new immunodeficient mouse model for human myoblast transplantation", HUM GENE TH, 12(7), 2001, pp. 823-831

Abstract

Design of efficient transplantation strategies for myoblast-based gene therapies in humans requires animal models in which xenografts are tolerated for long periods of time. In addition, such recipients should be able to withstand pretransplantation manipulations for enhancement of graft growth. Here we report that a newly developed immunodeficient mouse carrying two known mutations (the recombinase activating gene 2, RAG2, and the common cytokine receptor gamma, gammac) is a candidate fulfilling these requirements. Skeletal muscles from RAG2(-/-)/gammac(-/-) double mutant mice recover normally after myotoxin application or cryolesion, procedures commonly used to induce regeneration and improve transplantation efficiency. Well-differentiated donor-derived muscle tissue could be detected up to 9 weeks after transplantation of human myoblasts into RAG2(-/-)/gammac(-/-) muscles. These results suggest that the RAG2(-/-)/gammac(-/-) mouse model will provide new opportunities for human muscle research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:17:51