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Titolo:
Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro
Autore:
Moradpour, D; Grabscheid, B; Kammer, AR; Schmidtke, G; Groettrup, M; Blum, HE; Cerny, A;
Indirizzi:
Univ Freiburg, Dept Med 2, Freiburg, Germany Univ Freiburg Freiburg Germany Freiburg, Dept Med 2, Freiburg, Germany Univ Hosp Bern, Dept Internal Med, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 l Med, CH-3010 Bern, Switzerland Cantonal Hosp, Res Dept, St Gallen, Switzerland Cantonal Hosp St Gallen Switzerland p, Res Dept, St Gallen, Switzerland
Titolo Testata:
HEPATOLOGY
fascicolo: 5, volume: 33, anno: 2001,
pagine: 1282 - 1287
SICI:
0270-9139(200105)33:5<1282:EOHCVP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTRUCTURAL 5A PROTEIN; HUMAN CELL-LINES; TIGHTLY REGULATED EXPRESSION; T-LYMPHOCYTE RESPONSE; IMMUNE-RESPONSE; VIRAL CLEARANCE; MAMMALIAN-CELLS; GENE-PRODUCT; PKR; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Cerny, A Osped Civ, Med Clin, Via Tesserete 46, CH-6903 Lugano, Switzerland Osped Civ Via Tesserete 46 Lugano Switzerland CH-6903 witzerland
Citazione:
D. Moradpour et al., "Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro", HEPATOLOGY, 33(5), 2001, pp. 1282-1287

Abstract

Hepatitis C virus (HCV) infection takes a chronic course in the majority of patients, The mechanisms underlying the evasion of the host immune response and viral persistence are poorly understood. In this context, we investigated interactions of HCV proteins with major histocompatibility complex (MHC) class T processing and presentation pathways using cell lines that allow the tetracycline-regulated expression of viral structural and nonstructural proteins. These well-characterized inducible cell lines were found to efficiently process and present endogenously synthesized HCV proteins via MHCclass I. Functional MHC class I cell-surface expression and intracellular proteasome activity were not affected by the expression of HCV proteins. These results suggest that viral evasion of the host immune response does notinvolve interactions of HCV with MHC class I processing and presentation. Other mechanisms, such as interference with the interferon system, may be operative in HCV infection, leading to viral persistence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:40:29