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Titolo:
Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi
Autore:
Shoda, J; Oda, K; Suzuki, H; Sugiyama, Y; Ito, K; Cohen, DE; Feng, L; Kamiya, J; Nimura, Y; Miyazaki, H; Kano, M; Matsuzaki, Y; Tanaka, N;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Gastroenterol, Tsukuba, Ibaraki 3058575,Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 Tsukuba, Ibaraki 3058575,Japan Nagoya Univ, Sch Med, Dept Surg 1, Aichi, Japan Nagoya Univ Aichi JapanNagoya Univ, Sch Med, Dept Surg 1, Aichi, Japan Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Biopharmaceut, Tokyo, Japan UnivTokyo Tokyo Japan Pharmaceut Sci, Dept Biopharmaceut, Tokyo, Japan Albert Einstein Coll Med, Liver Res Ctr, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Res Ctr, Bronx, NY 10467 USA Niigata Coll Pharm, Dept Analyt Chem, Niigata 95021, Japan Niigata Coll Pharm Niigata Japan 95021 Analyt Chem, Niigata 95021, Japan
Titolo Testata:
HEPATOLOGY
fascicolo: 5, volume: 33, anno: 2001,
pagine: 1194 - 1205
SICI:
0270-9139(200105)33:5<1194:ESODIC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLCHOLINE TRANSFER PROTEIN; RESISTANCE-ASSOCIATED PROTEIN; TISSUE-SPECIFIC EXPRESSION; STEROL CARRIER PROTEIN-2; P-GLYCOPROTEIN GENE; CDNA CLONING; EXPORT PUMP; EAST-ASIA; GALLSTONES; TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Shoda, J Univ Tsukuba, Inst Clin Med, Dept Gastroenterol, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba IbarakiJapan 3058575 , Japan
Citazione:
J. Shoda et al., "Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi", HEPATOLOGY, 33(5), 2001, pp. 1194-1205

Abstract

Intrahepatic calculi, highly prevalent in the Far East, including Japan, are characterized clinically by chronic proliferative cholangitis with frequent stone recurrences. Intrahepatic calculi consist of 2 groups, i.e., brown pigment stones, including a high cholesterol content, and cholesterol stones, with the former predominating. To gain insights into the pathogenesis of intrahepatic calculi, cholesterol and bile acid biosynthesis, as well asalterations in intracellular transport and/or canalicular secretion of phospholipid and bile acid were investigated in liver of patients with intrahepatic calculi. Enzyme activities of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase were increased (12.8 +/- 1.9 pmol/min/mg protein, mean +/- SEM vs. 5.5 +/- 0.4 in controls; P < .01) and cholesterol 7 alpha -hydroxylase activities were decreased (1.3 +/- 0.4 vs. 4.9 +/- 0.6; P < .01) in liver specimens of patients with brown pigment stones. In addition, messenger RNA (mRNA) levels of multidrug resistance P-glycoprotein 3 (MDR3 Pgp) and phosphatidylcholine transfer protein (PCTP) were markedly low in the liver specimens compared with the levels in specimens of control subjects, gallbladder stone patients, and patients with obstructive cholestasis. The protein levels and the immunohistochemical staining were decreased for MDR3 Pgpand PCTP in the liver. Consistently, the concentrations of phospholipid were markedly reduced in the hepatic bile from both affected and unaffected hepatic segments. In patients with intrahepatic calculi, biliary cholesterolsupersaturation and the formation of cholesterol-rich brown pigment as well as cholesterol stones may be attributed to decreased hepatic transport and biliary secretion of phospholipids, in the setting of increased cholesterogenesis and decreased bile acid synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:56:30