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Titolo:
MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily
Autore:
Stone, B; Schummer, M; Paley, PJ; Crawford, M; Ford, M; Urban, N; Nelson, BH;
Indirizzi:
Virginia Mason Res Ctr, Seattle, WA 98101 USA Virginia Mason Res Ctr Seattle WA USA 98101 es Ctr, Seattle, WA 98101 USA Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ol Biotechnol, Seattle, WA 98195 USA Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 tet & Gynecol, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Canc Prevent Res Program, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Univ Washington, Dept Immunol, Marsha Rivkin Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ha Rivkin Ctr, Seattle, WA 98195 USA
Titolo Testata:
GENE
fascicolo: 2, volume: 267, anno: 2001,
pagine: 173 - 182
SICI:
0378-1119(20010418)267:2<173:MANUEM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRESENTATIONAL-DIFFERENCE ANALYSIS; NEURONAL GROWTH SUPPRESSOR; TUMOR-SPECIFIC EXPRESSION; T-CELL RESPONSES; POSTMITOTIC NEURONS; MELANOMA PATIENTS; NECDIN GENE; PHASE-I; FAMILY; ANTIGENS;
Keywords:
tumor; MAGE; ovary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stone, B Virginia Mason Res Ctr, 1201 9th Ave, Seattle, WA 98101 USA Virginia Mason Res Ctr 1201 9th Ave Seattle WA USA 98101 8101 USA
Citazione:
B. Stone et al., "MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily", GENE, 267(2), 2001, pp. 173-182

Abstract

Most known members of the MAGE superfamily are expressed in tumors, testisand fetal tissues, which has been described as a cancer/testis or 'CT' expression pattern. We have identified a novel member of this superfamily, MAGE-F1, which is expressed in all adult and fetal tissues tested. In additionto normal tissues, MAGE-F1 is expressed in many tumor types including ovarian, breast, cervical, melanoma and leukemia. MAGE-F1 is encoded on chromosome 3, identifying a sixth chromosomal location for a MAGE superfamily gene. The coding region of MAGE-F1 is contained within a single exon and includes a microsatellite repeat. Sequence analysis and expression profiles define a new class of ubiquitously expressed MAGE superfamily genes that includes MAGE-F1, MAGE-D1, MAGE-D2/JCL-1 and NDN. The finding that several MAGE genes are ubiquitously expressed suggests a role for MAGE encoded proteins innormal cell physiology. Furthermore, potential cross-reactivity to these ubiquitously expressed MAGE gene products should be considered in the designof MAGE-targeted immunotherapies for cancer. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:31:44