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Titolo:
Patients with alcoholic liver disease hospitalized in Hepatogastroenterology. A French national multicenter investigation
Autore:
Naveau, S; Giraud, V; Ganne, N; Perney, P; Hastier, P; Robin, E; Pessione, F; Chossegros, P; Lahmek, P; Fontaine, H; Ribard, D; Dao, T; Filoche, B; El Jammal, G; Seyrig, JA; Dramard, JM; Chousterman, M; Pillegand, B;
Indirizzi:
Hop Antoine Beclere, Serv Hepatogastroenterol, F-92141 Clamart, France HopAntoine Beclere Clamart France F-92141 erol, F-92141 Clamart, France Hop Jean Verdier, Bondy, France Hop Jean Verdier Bondy FranceHop Jean Verdier, Bondy, France Hop St Eloi, Serv Med Interne E, Montpellier, France Hop St Eloi Montpellier France Serv Med Interne E, Montpellier, France Hop Archet, Serv Hepatogastroenterol, Nice, France Hop Archet Nice France p Archet, Serv Hepatogastroenterol, Nice, France Hop Fontaine, Serv Hepatogastroenterol, St Denis, Reunion Hop Fontaine StDenis Reunion rv Hepatogastroenterol, St Denis, Reunion Hop Beaujon, Clichy, France Hop Beaujon Clichy FranceHop Beaujon, Clichy, France Hotel Dieu, Lyon, France Hotel Dieu Lyon FranceHotel Dieu, Lyon, France Hop Tenon, F-75970 Paris, France Hop Tenon Paris France F-75970Hop Tenon, F-75970 Paris, France Hop Necker Enfants Malad, Paris, France Hop Necker Enfants Malad Paris France cker Enfants Malad, Paris, France Hop Caremeau, Nimes, France Hop Caremeau Nimes FranceHop Caremeau, Nimes, France Ctr Hosp Reg, Caen, France Ctr Hosp Reg Caen FranceCtr Hosp Reg, Caen, France Hop St Philibert, Lomme Les Lille, France Hop St Philibert Lomme Les Lille France libert, Lomme Les Lille, France Hop Gen, Dijon, France Hop Gen Dijon FranceHop Gen, Dijon, France Hop Jegourel, Pontivy, France Hop Jegourel Pontivy FranceHop Jegourel, Pontivy, France Hop Intercommunal Val Ariege, St Jean De Verges, France Hop Intercommunal Val Ariege St Jean De Verges France De Verges, France Hop Intercommunal, Creteil, France Hop Intercommunal Creteil FranceHop Intercommunal, Creteil, France Hop Dupuytren, Limoges, France Hop Dupuytren Limoges FranceHop Dupuytren, Limoges, France
Titolo Testata:
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
fascicolo: 2, volume: 25, anno: 2001,
pagine: 131 - 136
SICI:
0399-8320(200102)25:2<131:PWALDH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
FRE
Soggetto:
HEPATITIS-C VIRUS; FIBROSIS; CIRRHOSIS; RISK; ANTIBODIES; STEATOSIS; DIAGNOSIS; INDEX;
Keywords:
alcoholic liver disease; epidemiological investigation; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Naveau, S Hop Antoine Beclere, Serv Hepatogastroenterol, 157 Rue Porte Trivaux, F-92141 Clamart, France Hop Antoine Beclere 157 Rue Porte Trivaux Clamart France F-92141
Citazione:
S. Naveau et al., "Patients with alcoholic liver disease hospitalized in Hepatogastroenterology. A French national multicenter investigation", GASTRO CL B, 25(2), 2001, pp. 131-136

Abstract

Objectives - To describe the characteristics of in-patients with alcoholicliver disease in Hepatogastroenterology and to evaluate whether geographiclocation was a risk Factor for cirrhosis. Methods - A French, national, multicenter, prospective investigation was performed in the last quarter of 1997. To be included in the study, patientshad to have drunk at least 50 g of alcohol per day for the past year or tohave cirrhosis. Results - Seventeen centers included 802 patients 20% had histologically proven cirrhosis or probable cirrhosis. Thirty-five percent had undergone liver biopsy. Twenty Five percent of these patients had cirrhosis without acute alcoholic hepatitis and 37% had cirrhosis with acute alcoholic hepatitis. After dividing France along a Bordeaux-Strasbourg axis, there was more histologically proven or probable cirrhosis in the North (46%) than in the South (36%) (P < 0.005) while daily alcohol intake was greater the South (150+/- 6 g) than in the North (129 +/- 4 g) (P < 0.0001). When the six variables (age, sex, daily consumption of alcohol over the past 5 years, presenceof hepatitis B surface antigen and antibodies to hepatitis C virus, total duration of alcohol abuse) were considered together in stepwise logistic regression analysis, geographic location changed the prediction of cirrhosis. The odds ratio for cirrhosis in patients living to the North of the Bordeaux-Strasbourg axis was 1.9 (95% confidence interval range 1.1-3.2) (P < 0.02), suggesting the role of nutritional factors.

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Documento generato il 05/12/20 alle ore 04:29:11