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Titolo:
Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease
Autore:
Torres, VE; Cowley, BD; Branden, MG; Yoshida, I; Gattone, VH;
Indirizzi:
Mayo Clin & Mayo Fdn, Nephrol Res Unit, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Unit, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Div Nephrol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 hrol, Rochester, MN 55905 USA Univ Kansas, Med Ctr, Dept Med, Kansas City, KS 66103 USA Univ Kansas Kansas City KS USA 66103 Dept Med, Kansas City, KS 66103 USA Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66103 USA Univ Kansas Kansas City KS USA 66103 Cell Biol, Kansas City, KS 66103 USA
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 3, volume: 9, anno: 2001,
pagine: 171 - 180
SICI:
1018-7782(2001)9:3<171:LACOSB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-FUNCTION; MURINE MODEL; RATS; PROGRESSION;
Keywords:
polycystic kidney disease; Han : SPRD rats; pcy/pcy mice; sodium bicarbonate; ammonium chloride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Torres, VE Mayo Clin & Mayo Fdn, Nephrol Res Unit, Plummer 549,200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Plummer 549,200 1st St SW Rochester MN USA 55905
Citazione:
V.E. Torres et al., "Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease", EXP NEPHROL, 9(3), 2001, pp. 171-180

Abstract

Administration of ammonium chloride aggravates, while short-term administration of sodium or potassium bicarbonate lessens the development of polycystic kidney disease in Han:SPRD rats. We have conducted studies to determinewhether the protection afforded by the administration of sodium bicarbonate is sustained and prevents development of uremia during chronic administration and whether the effects of the administration of ammonium chloride andsodium bicarbonate are also observed in a different model of polycystic kidney disease, the CD1-pcy/pcy mouse. We found that chronic administration of 200 mM sodium bicarbonate to Han:SPRD rats inhibited cystic enlargement and prevented the subsequent development of interstitial inflammation, chronic fibrosis, and uremia. We also found that, while the administration of ammonium chloride has similar effects in Han:SPRD rats and CD1-pcy/pcy mice, the administration of sodium bicarbonate is only protective in the Han:SPRDrats, This probably reflects differences in these models (predominately involvement of proximal tubules in Han:SPRD rats and of collecting ducts and distal tubules in pcy/pcy mice) and the different location and nature of the renal metabolic responses to the administration of acid or alkaline load. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:29:16