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Titolo:
Evolutionary theories of ageing applied to long-lived organisms
Autore:
Partridge, L;
Indirizzi:
Univ Coll London, Dept Biol, London NW1 2HE, England Univ Coll London London England NW1 2HE pt Biol, London NW1 2HE, England
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 4-6, volume: 36, anno: 2001,
pagine: 641 - 650
SICI:
0531-5565(200104)36:4-6<641:ETOAAT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
STANDARD METABOLIC-RATE; FREE-RADICAL PRODUCTION; DROSOPHILA-MELANOGASTER; LIFE-SPAN; CORRELATED RESPONSES; HEART-MITOCHONDRIA; MORTALITY-RATES; INNER MEMBRANE; SENESCENCE; SELECTION;
Keywords:
ageing; mutation-accumulation; pleiotropy; trade-offs; life histories; birds; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Partridge, L Univ Coll London, Dept Biol, Wolfson House,4 Stephenson Way, London NW1 2HE, England Univ Coll London Wolfson House,4 Stephenson Way London England NW1 2HE
Citazione:
L. Partridge, "Evolutionary theories of ageing applied to long-lived organisms", EXP GERONT, 36(4-6), 2001, pp. 641-650

Abstract

Ageing can evolve by mutation accumulation and pleiotropy (trade-offs). The relative prevalence of these two mechanisms is important for determining the likelihood that mechanisms of ageing are homologous in distantly related organisms, and hence the relevance of long-lived organisms to general mechanisms of ageing. Experimental work with Drosophila, examining the properties of standing genetic variation and mutations that accumulate in real time, has provided little evidence in favour of a role for mutation accumulation, but considerable support for the importance of trade-offs, particularlybetween early fertility and the rate of ageing. Evidence for the roles of these two processes in the evolution of long-livedness can be derived from the response to selection, comparative studies of life history traits and testing for potential trade-offs at the mechanistic level. (C) 2001 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 04:57:41