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Titolo:
The melanoma antigen genes - Any clues to their functions in normal tissues?
Autore:
Forslund, KO; Nordqvist, K;
Indirizzi:
Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm,Sweden Karolinska Inst Stockholm Sweden SE-17177 iol, SE-17177 Stockholm,Sweden
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 2, volume: 265, anno: 2001,
pagine: 185 - 194
SICI:
0014-4827(20010501)265:2<185:TMAG-A>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRADER-WILLI-SYNDROME; TUMOR-SPECIFIC EXPRESSION; HUMAN MAGE GENES; NECDIN GENE; NUCLEAR-PROTEIN; STEM-CELLS; POSTMITOTIC NEURONS; GROWTH SUPPRESSOR; T-LYMPHOCYTES; GERM-CELLS;
Keywords:
MAGE; necdin; p53; Rb; Mage-b4; tumor; melanoma; germ cell development;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Nordqvist, K Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm,Sweden Karolinska Inst Stockholm Sweden SE-17177 Stockholm,Sweden
Citazione:
K.O. Forslund e K. Nordqvist, "The melanoma antigen genes - Any clues to their functions in normal tissues?", EXP CELL RE, 265(2), 2001, pp. 185-194

Abstract

The melanoma antigen (MAGE) genes were initially isolated from melanomas and turned out to have an almost exclusively tumor-specific expression pattern. This led to the idea of using MAGE genes as targets for cancer immunotherapy, and MAGE peptides are currently being investigated as immunizing agents in clinical studies. Although 23 human and 12 mouse MAGE genes have been isolated in various tumors and characterized, not much is known about their function in normal cells. In adult tissues, most MAGE genes are expressed only in the testis and expression patterns suggest that this gene family is involved in germ cell development. In contrast to the MAGE genes, more functional data have accumulated around the MAGE related gene necdin. This gene encodes a neuron-specific growth suppressor that facilitates the entry of the cell into cell cycle arrest. Necdin is functionally similar to the retinoblastoma protein and binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. In this review me will focus on the normal functions of MAGE genes and me speculate, based on the patterns of MAGE expression and on observed functions of necdin, that this gene family is involvedin cell cycle regulation, especially during germ cell development. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:09:14