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Titolo:
Blunted adenosine A2a receptor function in platelets in patients with major depression
Autore:
Berk, M; Plein, H; Ferreira, D; Jersky, B;
Indirizzi:
Univ Witwatersrand, Dept Psychiat, ZA-2193 Johannesburg, South Africa UnivWitwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa Univ Witwatersrand, Dept Pharmacol, ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa Univ Sonoma, Dept Math, Sonoma, CA USA Univ Sonoma Sonoma CA USAUniv Sonoma, Dept Math, Sonoma, CA USA
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 183 - 186
SICI:
0924-977X(200104)11:2<183:BAARFI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERATION; INHIBITION; MECHANISMS; GENE;
Keywords:
adenosine; depression; mood; adenosine A2a receptor; calcium; intracellular signalling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Melbourne, Swanston Ctr, POB 281, Geelong, Vic 3220, Australia Univ Melbourne POB 281 Geelong Vic Australia 3220 3220, Australia
Citazione:
M. Berk et al., "Blunted adenosine A2a receptor function in platelets in patients with major depression", EUR NEUROPS, 11(2), 2001, pp. 183-186

Abstract

There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 muM dosage levels. This suggests that dysregulation of the adenosine A2a receptormay be present in depression. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:38:22