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Titolo:
Noradrenergic dysfunction and antidepressant treatment response
Autore:
Correa, H; Duval, F; Claude, MM; Bailey, P; Tremeau, F; Diep, TS; Crocq, MA; Castro, JO;
Indirizzi:
Univ Fed Minas Gerais, ICB, Dept Farmacol, BR-31270901 Belo Horizonte, MG,Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270901 BCe, MG,Brazil Univ Fed Minas Gerais, Dept Psiquiatria & Neurol, Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil elo Horizonte, MG, Brazil Ctr Hosp, Sect VIII, F-68250 Rouffach, France Ctr Hosp Rouffach France F-68250 sp, Sect VIII, F-68250 Rouffach, France Inst Res Neurosci & Psychiat, F-68250 Rouffach, France Inst Res Neurosci &Psychiat Rouffach France F-68250 50 Rouffach, France
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 163 - 168
SICI:
0924-977X(200104)11:2<163:NDAATR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE RESPONSE; MAJOR DEPRESSION; PANIC DISORDER; CATECHOLAMINE DEPLETION; ENDOGENOUS-DEPRESSION; GH RESPONSE; CLONIDINE; AMITRIPTYLINE; METABOLISM; FLUOXETINE;
Keywords:
major depression; clonidine stimulation test; noradrenergic function; antidepressant response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Correa, H Univ Fed Minas Gerais, ICB, Dept Farmacol, Ave Antonio Carlos,6627 CEP, BR-31270901 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Ave Antonio Carlos,6627 CEP Belo Horizonte MG Brazil BR-31270901 BC
Citazione:
H. Correa et al., "Noradrenergic dysfunction and antidepressant treatment response", EUR NEUROPS, 11(2), 2001, pp. 163-168

Abstract

The purpose of this study was to investigate differences in outcome following treatment with two different antidepressants in depressed patients according to their pretreatment hormonal response to clonidine. In all, 62 drug-free DSM-IV recurrent major depressed patients and 20 normal controls werestudied. Patients were subsequently treated for 4 weeks with fluoxetine (n=28), or amitriptyline (n=33), and were then classified as responders or nonresponders according to their final Hamilton depression scale score. Compared to controls, depressed patients showed lower CU response to CLO (Delta GH) (P<0.0002). One control (5%) and 35 depressed patients (56%) had blunted <Delta>GHI values. The efficacy of the two antidepressants was not significantly different: 15 patients responded to AMI (44%), seven patients responded to FLUOX (25%) (P>0.15). However, in the subgroup of patients with blunted Delta GH levels, the rate of responders was higher for AMI (11/21) compared, to FLUOX (1/14) treated patients (P<0.01). These results suggest that in depressed patients a blunted GH It sponse to CLO could predict antidepressant response. <(c)> 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 23/01/20 alle ore 03:44:11