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Titolo:
Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) - Acute placebo-controlled sleep laboratory studies with clonazepam
Autore:
Saletu, M; Anderer, P; Saletu-Zyhlarz, G; Prause, W; Semler, B; Zoghlami, A; Gruber, G; Hauer, C; Saletu, B;
Indirizzi:
Univ Vienna, Sch Med, Dept Psychiat, Sect Sleep Res & Pharmacopsychiat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 armacopsychiat, A-1090 Vienna, Austria Innsbruck Univ, Dept Neurol, Sect Sleep Res, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 p Res, A-6020 Innsbruck, Austria
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 153 - 161
SICI:
0924-977X(200104)11:2<153:RLS(AP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERALIZED ANXIETY DISORDER; PLUS DIPHENHYDRAMINE SOMNIUM(R); DOUBLE-BLIND; NONORGANIC INSOMNIA; MYOCLONUS; CARBAMAZEPINE; GABAPENTIN; DEFINITION; LORAZEPAM; THERAPY;
Keywords:
restless legs syndrome; periodic limb movement disorder; clonazepam; polysomnography; psychometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Saletu, B Univ Vienna, Sch Med, Dept Psychiat, Sect Sleep Res & Pharmacopsychiat, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
M. Saletu et al., "Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) - Acute placebo-controlled sleep laboratory studies with clonazepam", EUR NEUROPS, 11(2), 2001, pp. 153-161

Abstract

Restless legs syndrome (RLS) - a common sensorimotor disorder - and periodic limb movement disorder (PLMD) are currently treated with substances of four classes: dopaminergic agents, which are considered the drugs of choice,benzodiazepines, opioids and anticonvulsants. As their effects on sleep variables differ considerably, the aim of the present placebo-controlled sleep laboratory study was to measure the acute effects of 1 mg clonazepam on objective and subjective sleep and awakening quality in ten RLS and 16 PLMD patients, utilizing polysomnography (PSC) and psychometry. Descriptive dataanalysis demonstrated at the confirmatory level concerning three target variables that - as compared with placebo - clonazepam significantly improvedobjective sleep efficiency and subjective sleep quality in both patient groups, but failed to reduce the index PLM/h of sleep. At the descriptive level, in PLMD clonazepam improved PLM during rime in bed, REM and wakefulnessand showed more significant changes in various sleep and awakening measures than in RLS patients, though there were no significant inter-group differences. In conclusion, in both PLMD and RLS clonazepam exhibited acute therapeutic efficacy regarding insomnia, which is quite different from the mode of action of dopamine agonists. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 21:44:19