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Titolo:
Involvement of 5HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice
Autore:
Clenet, F; De Vos, A; Bourin, M;
Indirizzi:
Fac Med, Fac Med & GIS Medicament, F-44035 Nantes 01, France Fac Med Nantes France 01 Med & GIS Medicament, F-44035 Nantes 01, France
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 145 - 152
SICI:
0924-977X(200104)11:2<145:IO5RIT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT2C RECEPTOR; AGONISTS; RATS; MODEL; DEPRESSION; FLUOXETINE; SUBTYPES; BEHAVIOR; PROTEIN;
Keywords:
antidepressants; forced swimming test; mice; serotonin (5-HT); 5-HT2C receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bourin, M Fac Med, Fac Med & GIS Medicament, JE 2029 Neurobiol Anxiete,BP 53508,1 Rue Gaston V, F-44035 Nantes 01, France Fac Med JE 2029 Neurobiol Anxiete,BP 53508,1 Rue Gaston V Nantes France 01
Citazione:
F. Clenet et al., "Involvement of 5HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice", EUR NEUROPS, 11(2), 2001, pp. 145-152

Abstract

Several recent studies have demonstrated that 5-H-1A, 5-H-1B and 5-HT3 receptors were implicated in the mechanism of action of antidepressants in themouse forced swimming test. Despite extensive evidence for a role of 5-HT2C receptors in depression. the precise role of these receptors in the effects Of clinically established antidepressants was not directly investigated in the mouse forced swimming test. This work was aimed at exploring interactions between several doses of Ro 60-0175, a recently available, full and selective 5-HT2C agonist, and antidepressant drugs in the mouse forced swimming test. Spontaneous locomotor activity was measured as an index of intactsensorimotor functions and the dose-effect of Ro 60-0175 alone, as well asinteractions with several antidepressants, such as tricyclic antidepressants (imipramine, desipramine and maprotiline) and selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, fluvoxamine and sertraline), were studied in the mouse forced swimming test. There was no intrinsicantidepressant-like effect of Ro 60-0175, but an impairment in locomotor function was detected when using doses higher than 4 mg/kg in the mouse. There was a synergistic effect of low doses of Ro 60-0175 with sub-active doses of imipramine, paroxetine, citalopram and fluvoxamine; an antagonism between the highest dose of Ro 60-0175 and the active doses of paroxetine and fluoxetine was also detected. There is evidence that 5-HT2C receptors may beinvolved in the action of antidepressants which are able to boost the concentration of serotonin in the synapse, i.e. SSRIs: and imipramine (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:57:26