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Titolo:
A follow up study of suicide attempters: Increase of CSF-somatostatin but no change in CSF-CRH
Autore:
Westrin, A; Ekman, R; Regnell, G; Traskman-Bendz, L;
Indirizzi:
Univ Lund, Dept Clin Neurosci, Div Psychiat, Lund, Sweden Univ Lund LundSweden d, Dept Clin Neurosci, Div Psychiat, Lund, Sweden Univ Gothenburg, Dept Psychiat & Neurochem, Inst Clin Neurosci, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden nst Clin Neurosci, Gothenburg, Sweden
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 135 - 143
SICI:
0924-977X(200104)11:2<135:AFUSOS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; CEREBROSPINAL-FLUID SOMATOSTATIN; FACTOR-LIKE IMMUNOREACTIVITY; DEPRESSED-PATIENTS; MAJOR DEPRESSION; MONOAMINE METABOLITES; ALZHEIMERS-DISEASE; ADRENOCORTICOTROPIN SECRETION; NEUROPEPTIDE CONCENTRATIONS; SCHIZOPHRENIC-PATIENTS;
Keywords:
suicide attempt; follow-up; corticotrophin-releasing hormone; somatostatin; hypothalamic-pituitary-adrenocortical axis; major depressive disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Westrin, A Univ Lund, Dept Clin Neurosci, Div Psychiat, Lund, Sweden Univ Lund Lund Sweden n Neurosci, Div Psychiat, Lund, Sweden
Citazione:
A. Westrin et al., "A follow up study of suicide attempters: Increase of CSF-somatostatin but no change in CSF-CRH", EUR NEUROPS, 11(2), 2001, pp. 135-143

Abstract

Concentrations of somatostatin and corticotrophin releasing hormone (CRH),measured in cerebrospinal fluid (CSF) have been reported to be low in suicidal patients with major depressive disorder (MDD). Often have MDD patientsin general, high CSF-CRH and low CSF-somatostatin concentrations, which both seem to normalise with clinical recovery. The present study was designedto look for CSF-CRI-I and CSF-somatostatin alterations along with clinicalchanges in patients studied repeatedly after a suicide attempt. Sixteen patients with different diagnoses, initially inpatients after a suicide attempt (baseline), participated. Lumbar punctures and ratings according to the Suicidal Assessment Scale (SUAS) and the Montgomery-Asberg Depression Rating Scale (MADRS) were performed while patients were drug-frre (baseline) anti after a median of 7 (5 to 9) months. At follow up MADRS- and SUAS-scores were significantly decreased (P<0.05), whereas CSF-somatostatin was significantly increased (P=0.013) and CSF-CRH had not changed significantly. Thus,the patients showed long-lasting low CSF-CRH concentrations, in spite of changed CSF-somatostatin concentrations and clinical amelioration. <(c)> 2001 Elsevier Science B,V. All rights reserved.

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Documento generato il 20/11/19 alle ore 02:28:43