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Titolo:
New hypotheses for the GPCR 3D arrangement based on a molecular model of the human sweet-taste receptor
Autore:
Nofre, C;
Indirizzi:
Univ Lyon 1, Fac Med Lyon Laennec, Lyon, France Univ Lyon 1 Lyon FranceUniv Lyon 1, Fac Med Lyon Laennec, Lyon, France
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 2, volume: 36, anno: 2001,
pagine: 101 - 108
SICI:
0223-5234(200102)36:2<101:NHFTG3>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; 3-DIMENSIONAL MODELS; PSEUDO-SUGARS; BETA-D; RHODOPSIN; SUCROSE; BACTERIORHODOPSIN; TRANSDUCTION; HELICES;
Keywords:
G protein-coupled receptors; sweet-taste receptors; molecular modelling; drug design;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nofre, C 114 Cours Albert Thomas, F-69008 Lyon, France 114 Cours Albert Thomas Lyon France F-69008 -69008 Lyon, France
Citazione:
C. Nofre, "New hypotheses for the GPCR 3D arrangement based on a molecular model of the human sweet-taste receptor", EUR J MED C, 36(2), 2001, pp. 101-108

Abstract

A molecular model of the human sweet-taste receptor has been inferred fromsuperpositions of 3D maps of sweetener interaction sites (themselves previously deduced from extensive structure-activity relationship studies on highly potent sweeteners) onto three well-known G protein-coupled receptors (GPCRs) - rhodopsin, beta (2)- and alpha (2A)-adrenergic receptors - assumed to be linked by common evolutionary origins. The model gives new answers toold questions on the GPCR 3D structure, such as on the orientation and arrangement of the binding helices, their interaxial distances, radial orientations and relative heights. The model should be useful as a new approach tothe rational design of drugs. (C) 2001 Editions scientifiques et medicalesElsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:21:11