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Titolo:
Municipal drinking water nitrate level and cancer risk in older women: TheIowa Women's Health Study
Autore:
Weyer, PJ; Cerhan, JR; Kross, BC; Hallberg, GR; Kantamneni, J; Breuer, G; Jones, MP; Zheng, W; Lynch, CF;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Res, Rochester, MN 55905 USA Univ Iowa, Ctr Hlth Effects Environm Contaminat, Iowa City, IA USA Univ Iowa Iowa City IA USA ffects Environm Contaminat, Iowa City, IA USA Univ Iowa, Hyg Lab, Iowa City, IA USA Univ Iowa Iowa City IA USAUniv Iowa, Hyg Lab, Iowa City, IA USA Univ Iowa, Coll Publ Hlth, Iowa City, IA USA Univ Iowa Iowa City IA USAUniv Iowa, Coll Publ Hlth, Iowa City, IA USA Cadmus Grp Inc, Waltham, MA USA Cadmus Grp Inc Waltham MA USACadmus Grp Inc, Waltham, MA USA Vanderbilt Univ, Hlth Serv Res, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Hlth Serv Res, Nashville, TN USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 327 - 338
SICI:
1044-3983(200105)12:3<327:MDWNLA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-NITROSO COMPOUNDS; CHLORINATION BY-PRODUCTS; GASTRIC-CANCER; FERTILIZER MANUFACTURERS; POSTMENOPAUSAL WOMEN; ENDOMETRIAL CANCER; OVARIAN-CANCER; WELL-WATER; MORTALITY; DIET;
Keywords:
nitrate; N-nitroso compounds; neoplasms; drinking water; cohort study; environmental exposures; water contaminants; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Cerhan, JR Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 5 USA
Citazione:
P.J. Weyer et al., "Municipal drinking water nitrate level and cancer risk in older women: TheIowa Women's Health Study", EPIDEMIOLOG, 12(3), 2001, pp. 327-338

Abstract

Nitrate contamination of drinking water may increase cancer risk, because nitrate is endogenously reduced to nitrite and subsequent nitrosation reactions give rise to N-nitroso compounds; these compounds are highly carcinogenic and can act systemically. We analyzed cancer incidence in a cohort of 21,977 Iowa women who were 55-69 years of age at baseline in 1986 and had used the same water supply more than 10 years (87% > 20 years); 16,541 of these women were on a municipal supply, and the remainder used a private well. We assessed nitrate exposure from 1955 through 1988 using public databasesfor municipal water supplies in Iowa (quartile cutpoints: 0.36, 1.01, and 2.46 mg per liter nitrate nitrogen). As no individual water consumption data were available, we assigned each woman an average level of exposure calculated on a community basis; no nitrate data were available for women using private wells. Cancer incidence (N = 3,150 cases) from 1986 through 1998 was determined by linkage to the Iowa Cancer Registry. For all cancers, therewas no association with increasing nitrate in drinking water, nor were there clear and consistent associations for non-Hodgkin lymphoma; leukemia; melanoma; or cancers of the colon, breast, lung, pancreas, or kidney. There were positive associations for bladder cancer [relative risks (RRs) across nitrate quartiles = 1, 1.69, 1.10, and 2.83] and ovarian cancer (RR = 1, 1.52, 1.81, and 1.84), and inverse associations for uterine cancer (RR = 1, 0.86, 0.86, and 0.55) and rectal cancer (RR = 1, 0.72, 0.95, and 0.47) after adjustment for a variety of cancer risk/protective factors, agents that affect nitrosation (smoking, vitamin C, and vitamin E intake), dietary nitrate, and water source. Similar results were obtained when analyses were restricted to nitrate level in drinking water from 1955 through 1964. The positive association for bladder cancer is consistent with some previous data; theassociations for ovarian, uterine, and rectal cancer were unexpected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 22:45:50