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Titolo:
Effects of developmental lead exposure on inhibitory avoidance learning and glutamate receptors in rats
Autore:
Chen, HH; Ma, TG; Ho, IK;
Indirizzi:
Tzu Chi Univ, Inst Toxicol, Hualien 970, Taiwan Tzu Chi Univ Hualien Taiwan 970 Univ, Inst Toxicol, Hualien 970, Taiwan Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USAUniv Mississippi Jackson MS USA 39216 ol & Toxicol, Jackson, MS 39216 USA
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 9, anno: 2001,
pagine: 185 - 191
SICI:
1382-6689(200103)9:4<185:EODLEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; H-3 MK-801 BINDING; PB-INDUCED CHANGES; PROTEIN-KINASE-C; AMPA RECEPTOR; HIPPOCAMPAL-NEURONS; ENTORHINAL CORTEX; NMDA-RECEPTORS; ADULT-RAT; IN-VIVO;
Keywords:
lead; avoidance learning; AMPA receptor; NMDA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, HH Tzu Chi Univ, Inst Toxicol, 701,3 Chung Yang Rd, Hualien 970, Taiwan Tzu Chi Univ 701,3 Chung Yang Rd Hualien Taiwan 970 970, Taiwan
Citazione:
H.H. Chen et al., "Effects of developmental lead exposure on inhibitory avoidance learning and glutamate receptors in rats", ENV TOX PH, 9(4), 2001, pp. 185-191

Abstract

Chronic lead (Pb) exposure during development is known to produce learningdeficits. AMPA and NMDA receptors have been shown to participate in the synaptic mechanisms involved in certain forms of learning and memory. We investigated whether the effects of Pb on AMPA and NMDA receptors are associated with Pb-induced impairment in learning and memory. Rats were exposed to 0.2% lead acetate at different developmental stages including a maternally exposed group (including gestation and lactation period), a postweaning exposed group, and a continuously exposed group. Lead treatment impaired learning acquisition, but not memory retention in step-down avoidance learning task in all treatment groups. In parallel with the behavioral data, autoradiographic analyses of brain sections indicated that the [H-3]AMPA binding wasdecreased in the CA1 and dentate gyrus of the hippocampus and entorhinal cortex in all three Pb-exposed groups. However, an increase in [H-3]MK801 binding was only observed in CA1 of the hippocampus in the continuously Pb-exposed rats. The findings suggest that alterations in AMPA receptor may contribute to the Pb-induced deficits in learning acquisition of inhibitory avoidance. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:57:56