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Titolo:
Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats
Autore:
Pande, M; Mehta, A; Pant, BP; Flora, SJS;
Indirizzi:
Def Res & Dev Estab, Div Pharmacol & Toxicol, Gwalior 474002, India Def Res & Dev Estab Gwalior India 474002 Toxicol, Gwalior 474002, India Def Res & Dev Estab, Div Synthet Chem, Gwalior 474002, India Def Res & DevEstab Gwalior India 474002 het Chem, Gwalior 474002, India
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
fascicolo: 4, volume: 9, anno: 2001,
pagine: 173 - 184
SICI:
1382-6689(200103)9:4<173:CAOACA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESO-2,3-DIMERCAPTOSUCCINIC ACID; DIMERCAPTOSUCCINIC ACID; MONOALKYL ESTERS; MONOISOAMYL MESO-2,3-DIMERCAPTOSUCCINATE; 2,3-DIMERCAPTOSUCCINIC ACID; LIPID-PEROXIDATION; OXIDATIVE STRESS; N-ACETYLCYSTEINE; MOBILIZATION; EXPOSURE;
Keywords:
acute lead toxicity; prevention and treatment; combined administration; n-acetylcysteine; thiol chelator; biochemical variables; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Flora, SJS Def Res & Dev Estab, Div Pharmacol & Toxicol, Jhansi Rd, Gwalior 474002, India Def Res & Dev Estab Jhansi Rd Gwalior India 474002 4002, India
Citazione:
M. Pande et al., "Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats", ENV TOX PH, 9(4), 2001, pp. 173-184

Abstract

The administration of chelating agents, meso 2,3-dimercaptosuccinic acid (DMSA), monoisoamyl DMSA (MiADMSA) either individually or in combination with an antioxidant, n-acetylcysteine (NAC) in the prevention and treatment ofacute lead intoxication in rats, was investigated. The results suggest that concomitant oral supplementation of DMSA with lead was most effective in preventing the inhibition of lead sensitive blood S-aminolevulinic acid dehydratase (ALAD) activity in blood, elevation of zinc protoporphyrin level and the alterations in hepatic reduced and oxidized glutathione (GSH and GSSG) contents. A number of other biochemical variables either remained insensitive to lead exposure or responded moderately to chelation treatment. Combined administrations of NAC plus DMSA alas most effective when given duringlead exposure of post exposure, followed by DMSA and MiADMSA alone or NAC plus MiADMSA treatment, in reducing the accumulation of lead in blood and liver. Administration of NAC alone was only mildly effective in preventing lead absorption in the blood and tissues. The results suggest that combined administration of DMSA and NAC could be a more effective treatment protocolfor acute lead toxicity, keeping in view its beneficial effect on oxidative injury. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:22:59