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Titolo:
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats
Autore:
Gerak, LR; Woolverton, WL; Nader, MA; Patrick, GA; Harris, LS; Winger, G; Woods, JH; France, CP;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Human Behav, Jackson, MS 39216 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 63, anno: 2001,
pagine: 39 - 49
SICI:
0376-8716(20010601)63:1<39:BEOFRA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM THERAPEUTIC USE; BENZODIAZEPINE RECEPTOR; DRUG DISCRIMINATION; ABUSE LIABILITY; MIDAZOLAM; DIAZEPAM; SUBSTITUTION; TRIAZOLAM; BINDING;
Keywords:
flunitrazepam drug discrimination; self-administration; rhesus monkey; pentobarbital-dependent rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: France, CP Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 ns, LA 70112 USA
Citazione:
L.R. Gerak et al., "Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats", DRUG AL DEP, 63(1), 2001, pp. 39-49

Abstract

Flunitrazepam was evaluated in several procedures that have been used extensively to study the behavioral effects and abuse potential of positive GABA(A) modulators. One group of monkeys (n = 3) responded to receive injections of methohexital or saline (i.v.) while other groups (n = 2-4/group) discriminated vehicle from tither pentobarbital or triazolam. Other monkeys (n = 2) received diazepam daily and discriminated flumazenil from vehicle. Finally, the ability of flunitrazepam to prevent the emergence of withdrawal signs in pentobarbital-treated rats was evaluated. Flunitrazepam maintained i.v. self-administration that was, on average, less than that maintained bymethohexital and greater than that maintained by saline. In drug discrimination studies, flunitrazepam substituted for pentobarbital and for triazolam and failed to substitute fur flumazenil. In rats (n = 3-6/group), signs of withdrawal were not evident when flunitrazepam treatment replaced pentobarbital treatment: withdrawal signs emerged when either pentobarbital or flunitrazepam treatment was terminated. Taken together with data from previousstudies. these data suggest that the abuse liability of flunitrazepam is comparable to that of other benzodiazepines. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 28/01/20 alle ore 22:00:28