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Titolo:
High glucose induces ventricular instability and increases vasomotor tone in rats
Autore:
DAmico, M; Marfella, R; Nappo, F; Di Filippo, C; De Angelis, L; Berrino, L; Rossi, F; Giugliano, D;
Indirizzi:
Univ Naples 2, Dept Geriatr & Metab Dis, Naples, Italy Univ Naples 2 Naples Italy s 2, Dept Geriatr & Metab Dis, Naples, Italy Univ Naples 2, Dept Expt Med, Pharmacol Sect, Naples, Italy Univ Naples 2Naples Italy Dept Expt Med, Pharmacol Sect, Naples, Italy
Titolo Testata:
DIABETOLOGIA
fascicolo: 4, volume: 44, anno: 2001,
pagine: 464 - 470
SICI:
0012-186X(200104)44:4<464:HGIVIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUDDEN CARDIAC DEATH; NITRIC-OXIDE; QT INTERVAL; AUTONOMIC NEUROPATHY; ACUTE HYPERGLYCEMIA; DIABETES-MELLITUS; CARDIOVASCULAR MORTALITY; MYOCARDIAL-INFARCTION; SMOOTH-MUSCLE; RISK-FACTORS;
Keywords:
high glucose; diabetes; streptozotocin; cardiac repolarization; isolated heart;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Giugliano, D Via Emilia 1, I-80021 Afragola, NA, Italy Via Emilia 1 Afragola NA Italy I-80021 1 Afragola, NA, Italy
Citazione:
M. D'Amico et al., "High glucose induces ventricular instability and increases vasomotor tone in rats", DIABETOLOG, 44(4), 2001, pp. 464-470

Abstract

Aims/hypothesis. To investigate cardiac repolarization time in streptozotocin-induced diabetic rats and isolated hearts perfused with high glucose concentration. Methods. We studied the effects of streptozotocin-induced diabetes on the cardiac repolarisation time (Q-T interval) in Sprague-Dawley rats during a 4-day period of hyperglycaemia and a subsequent 4-day period ofnormoglycaemia. The Q-T interval was also evaluated in isolated hearts of non-diabetic rats, in condition of high glucose concentration. Results. Hyperglycaemia in streptozotocin rats increased mean blood pressure and led toa significant (p < 0.001) prolongation of Q-T values, which normalized after 4 days of normoglycaemia with intravenous insulin infusion. Perfusion ofisolated hearts in condition of high glucose concentration caused a significant prolongation of Q-T values and increased coronary perfusion pressure (p < 0.001). The effects of high glucose were completely prevented by glutathione and almost completely by L-arginine, the natural precursor of nitricoxide. In a condition of normal glucose, L-NAME, an inhibitor of endogenous nitric oxide synthesis, increased both Q-T and CPP values to levels similar to those induced by high glucose (p < 0.001). Verapamil completely prevented Q-T lengthening and reduced by about two-thirds CPP values (p < 0.001). Conclusion/Interpretation. Streptozotocin-diabetes in rats produces significant haemodynamic and electric perturbations that are reversed by normoglycaemia, Moreover, high glucose increases Q-T and CPP values in the isolatedhearts of non-diabetic rats. The latter effects are reversed by glutathione and L-arginine, partially reversed by verapamil and mimicked by L-NAME. By increasing the production of free radicals, high glucose could reduce nitric oxide availability to target cells inducing a state of increased vasomotor tone and ventricular instability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:49:10