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Titolo:
Expression and localization of proteoglycans during limb myogenic activation
Autore:
Olguin, H; Brandan, E;
Indirizzi:
Pontificia Univ Catolica Chile, Fac Biol Sci, Dept Cell & Mol Biol, Ctr Regulac Celular & Patol,MIFAB, Santiago, Chile Pontificia Univ Catolica Chile Santiago Chile ol,MIFAB, Santiago, Chile
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 1, volume: 221, anno: 2001,
pagine: 106 - 115
SICI:
1058-8388(200105)221:1<106:EALOPD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; HEPARAN-SULFATE PROTEOGLYCANS; SKELETAL-MUSCLE DIFFERENTIATION; FACTOR-DEPENDENT MECHANISM; MYOBLAST DIFFERENTIATION; FACTOR-BETA; TERMINAL DIFFERENTIATION; SYNDECAN-1 EXPRESSION; EXTRACELLULAR-MATRIX; DEVELOPING SOMITE;
Keywords:
myogenesis; limb formation; syndecans; decorin; growth factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Brandan, E Pontificia Univ Catolica Chile, Fac Biol Sci, Dept Cell & Mol Biol, Ctr Regulac Celular & Patol,MIFAB, POB 114-D, Santiago, Chile Pontificia Univ Catolica Chile POB 114-D Santiago Chile Chile
Citazione:
H. Olguin e E. Brandan, "Expression and localization of proteoglycans during limb myogenic activation", DEV DYNAM, 221(1), 2001, pp. 106-115

Abstract

After arriving at the limb bud, migrating myogenic precursor cells expresstranscription factors responsible for the induction of terminal skeletal muscle differentiation. One such factor is myogenin, a member of the basic helix-loop-helix family, known to activate the expression of muscle-specificgenes. The extracellular signals involved in activating the myogenic program in the muscle precursor cells that reach the limb in vivo are not known. However, in vitro, it has been shown that proteoglycans, macromolecules composed of a core protein and glycosaminoglycan chains, modulate the triggering of myogenin activity. To understand the role of proteoglycans during limb muscle development, we assessed the synthesis of proteoglycans in limb bud explants at 10.5 days post coitum, when migrating cells arrive, evaluated the expression and nature of these macromolecules during in vivo early limb bud formation, and determined the colocalization of myoblasts expressingmyogenin with specific proteoglycans. We found that the expression of myogenin was temporally and spatially coincident with the expression of syndecan-3 and decorin, two essential proteoglycans in the modulation of skeletal muscle differentiation. This article is the first report of myogenic activation and proteoglycan expression during limb muscle formation, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:14:58