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Titolo:
Tec kinases: modulators of lymphocyte signaling and development
Autore:
Lewis, CM; Broussard, C; Czar, MJ; Schwartzberg, PL;
Indirizzi:
NIH, Natl Human Genome Res Inst, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 l Human Genome Res Inst, Bethesda, MD 20892 USA NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 t, Res Scholars Program, Bethesda, MD 20892 USA
Titolo Testata:
CURRENT OPINION IN IMMUNOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 317 - 325
SICI:
0952-7915(200106)13:3<317:TKMOLS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRUTONS-TYROSINE-KINASE; PLECKSTRIN HOMOLOGY DOMAINS; HUMAN T-LYMPHOCYTES; B-CELL DEVELOPMENT; FAMILY KINASES; THYMOCYTE DEVELOPMENT; PLASMA-MEMBRANE; CALCIUM SIGNALS; MICE LACKING; SH2 DOMAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartzberg, PL NIH, Natl Human Genome Res Inst, Bldg 10, Bethesda, MD 20892 USA NIH Bldg 10 Bethesda MD USA 20892 Bethesda, MD 20892 USA
Citazione:
C.M. Lewis et al., "Tec kinases: modulators of lymphocyte signaling and development", CURR OP IM, 13(3), 2001, pp. 317-325

Abstract

The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which arerequired for activation of PLC-gamma and downstream pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:45:48