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Titolo:
Proximal protein tyrosine kinases it immunoreceptor signaling
Autore:
Latour, S; Veillette, A;
Indirizzi:
Clin Res Inst Montreal, Mol Oncol Lab, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal Montreal PQ Canada H2W 1R7 eal, PQ H2W 1R7, Canada Hop Necker Enfants Malad, INSERM, U429, Paris, France Hop Necker Enfants Malad Paris France alad, INSERM, U429, Paris, France
Titolo Testata:
CURRENT OPINION IN IMMUNOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 299 - 306
SICI:
0952-7915(200106)13:3<299:PPTKII>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN-RECEPTOR; FC-EPSILON-RI; B-CELL; NEGATIVE REGULATION; T-CELLS; C-CBL; MEMBRANE COMPARTMENTATION; SH2 DOMAINS; SYK; ACTIVATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Latour, S Clin Res Inst Montreal, Mol Oncol Lab, 110 Pine Ave W, Montreal,PQ H2W 1R7, Canada Clin Res Inst Montreal 110 Pine Ave W Montreal PQ Canada H2W 1R7
Citazione:
S. Latour e A. Veillette, "Proximal protein tyrosine kinases it immunoreceptor signaling", CURR OP IM, 13(3), 2001, pp. 299-306

Abstract

Immunoreceptor engagement results in the sequential activation of several classes of protein tyrosine kinases, including the Src and Syk/Zap-70 families. Recent progress has been made in our understanding of the regulation and function of these molecules. First, it was revealed that membrane compartmentation of protein tyrosine kinases may be essential for their proper biological function. Second, Src family kinases were found to act not only aspositive regulators, but also as inhibitors of cell activation. Third, it was appreciated that Csk, a potent inhibitor of Src kinases, is regulated by an assortment of protein-protein interactions. Fourth, differences in theregulation of Syk and Zap-70 were observed! suggesting significant distinctions in the purpose of these two kinases in immunoreceptor signaling. And fifth, it was suggested that proximal kinases implicated in immunoreceptor-mediated signal transduction may be regulated by protein degradation via binding to c-Cbl, a ubiquitin ligase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:06:50