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Titolo:
Generation, control, and processing of cellular calcium signals
Autore:
Carafoli, E; Santella, L; Branca, D; Brini, M;
Indirizzi:
Univ Padua, Dept Biochem, I-35121 Padua, Italy Univ Padua Padua Italy I-35121 Padua, Dept Biochem, I-35121 Padua, Italy Stn Zool A Dohrn, I-80121 Naples, Italy Stn Zool A Dohrn Naples Italy I-80121 ool A Dohrn, I-80121 Naples, Italy
Titolo Testata:
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 36, anno: 2001,
pagine: 107 - 260
SICI:
1040-9238(2001)36:2<107:GCAPOC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; SEA-URCHIN EGGS; CALMODULIN-BINDING DOMAIN; CHANNEL RYANODINE RECEPTOR; PHOSPHOLIPASE-C-GAMMA; SMOOTH-MUSCLE CELLS; MEMBRANE CA2+ PUMP; CYCLIC ADP-RIBOSE; AMINO-ACID-SEQUENCE;
Keywords:
calcium binding proteins; calcium transport; protein kinases and phosphatases; fertilization; memory and learning; cell death;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
971
Recensione:
Indirizzi per estratti:
Indirizzo: Carafoli, E Univ Padua, Dept Biochem, Via G Colombo 3, I-35121 Padua, Italy Univ Padua Via G Colombo 3 Padua Italy I-35121 1 Padua, Italy
Citazione:
E. Carafoli et al., "Generation, control, and processing of cellular calcium signals", CR R BIOCHE, 36(2), 2001, pp. 107-260

Abstract

In the course of evolution, Ca2+ has emerged as the most versatile intracellular messenger. Its concentration within cells is controlled by reversible binding to specific classes of proteins that act as Ca2+ sensors to decode its information before passing it on to targets. The decoding operation is based on specific conformational changes in the sensor proteins. Other proteins intrinsic to membranes simply control Ca2+ concentration without processing its message, by transporting it across membrane boundaries. They are located in the plasma membrane and in the membranes of the organelles (the endo(sarco)plasmic reticulum, the mitochondria, the nuclear envelope), which play distinctive roles in the cellular homeostasis of Ca2+. Ca2+ is an ambivalent signaling agent. It carries information to virtually all processes important to cell life (e.g., it couples excitation to contraction, secretion, gene transcription, and controls enzyme activity through protein phosphorylation-dephosphorylation), but also transmits signals that promote the programmed demise of cells. When escaping control, Ca2+ also precipitatestoxic cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:53:51