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Titolo:
Uncoupling protein1 mRNA, mitochondrial GTP-binding, and T-4 5 '-deiodinase of brown adipose tissue in euthermic Daurian ground squirrel during cold exposure
Autore:
Liu, XT; Li, QF; Lin, QS; Sun, RY;
Indirizzi:
Beijing Normal Univ, Coll Life Sci, Inst Ecol, Beijing 100875, Peoples R China Beijing Normal Univ Beijing Peoples R China 100875 0875, Peoples R China Acad Sinica, Shanghai Inst Biochem, State Key Lab Mol Biol, Shanghai 200031, Peoples R China Acad Sinica Shanghai Peoples R China 200031 ghai 200031, Peoples R China
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 4, volume: 128, anno: 2001,
pagine: 827 - 835
SICI:
1095-6433(200104)128:4<827:UPMMGA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE; MESSENGER-RNA; GDP-BINDING; THERMOGENESIS; AROUSAL; HIBERNATION; HAMSTER; SITES;
Keywords:
brown adipose tissue; cold exposure; Daurian ground squirrel; euthermic; GTP binding to mitochondria; hibernator; message RNA for uncoupling protein1; non-shivering thermogenesis; T4 5 '-deiodinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Li, QF Beijing Normal Univ, Coll Life Sci, Inst Ecol, 19 Xinwai St, Beijing 100875, Peoples R China Beijing Normal Univ 19 Xinwai St Beijing PeoplesR China 100875 na
Citazione:
X.T. Liu et al., "Uncoupling protein1 mRNA, mitochondrial GTP-binding, and T-4 5 '-deiodinase of brown adipose tissue in euthermic Daurian ground squirrel during cold exposure", COMP BIOC A, 128(4), 2001, pp. 827-835

Abstract

Regulation of thermogenic activity and uncoupling protein1 (UCP1) expression in brown adipose tissue (BAT) were studied in euthermic Daurian ground squirrel after acute and chronic cold exposure at 4 degreesC. The UCP1 concentration was indirectly determined by titration with its specific ligand [H-3]-labeled GTP, and Ucp1 mRNA was detected by using a [P-32]-labeled antisense oligonucleotide probe. Both acute and chronic cold exposure stimulatedup-regulation of Ucp1 mRNA, Although UCP1 concentration is not significantly increased after 24 h of cold exposure, it is markedly elevated by 75% insquirrels after 4-week cold adaptation compared with controls raised at 22degreesC. Changes in T-4 5'-deiodinase activity were closely associated with variations of Ucp1 mRNA level. Ucp1 gene expression is significantly affected by cold exposure in BAT from euthermic Daurian ground squirrels. In addition, the activation of T-4 5'-deiodinase may be an important regulatoryfactor in cold-induced Ucp1 expression. (C) 2001 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:34:37